Results 91 to 100 of about 1,015,464 (310)
Non-Local Sensitivity Analysis and Numerical Homogenization in Optimal Design of Single-Wall Corrugated Board Packaging. [PDF]
Materials (Basel), 2022 Mrówczyński D +2 more
europepmc +1 more source
Automated Sensitivity Analysis in Early Space Mission Design
, 2012 Concurrent Engineering in space mission design features several hundred design parameters provided by more than a dozen domain experts. The quality of the design strongly depends on the individual expertise of the people in the team, their experience and
Schaus, Volker +3 more
core
, 2008 In this work, we introduce a generalized rationale for local sensitivity analysis (SA) methods that allows to solve the problems connected with input constraints.
BORGONOVO, EMANUELE
core +1 more source
Molecular Oncology, EarlyView.Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena +15 more
wiley +1 more source
Molecular Oncology, EarlyView.Circulating tumor cells (CTCs) and plasma cell‐free DNA (cfDNA) were analyzed to detect ESR1 mutations and methylation in patients with advanced breast cancer. CTC‐derived DNA showed higher sensitivity for mutation detection and revealed complementary genetic and epigenetic alterations, highlighting the added value of CTC analysis for understanding ...
Dimitra Stergiopoulou +12 more
wiley +1 more source
Jurnal Teknologi PendidikanThis study aims to analyze the influence of local wisdom, environmental sensitivity, and disaster anticipation on social balance in Jember Regency. In this study, a social theory is used that underlies that local wisdom, environmental sensitivity, and ...
sukidin sukidin +2 more
doaj +1 more source
A Semiparametric Approach for Analyzing Nonignorable Missing Data [PDF]
In missing data analysis, there is often a need to assess the sensitivity of key inferences to departures from untestable assumptions regarding the missing data process.
Yi Qian, Hui Xie, Leming Qu
core
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Local sensitivity analysis and bias model selection [PDF]
, 2014 PhD ThesisIncomplete data analysis is often considered with other problems such as model uncertainty or non-identi ability. In this thesis I will use the idea of the local sensitivity analysis to address problems under both ignorable and non-ignorable
Yin, Peng
core
Molecular Oncology, EarlyView.Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata +10 more
wiley +1 more source