Results 101 to 110 of about 525,049 (314)
Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity
Molecular Oncology, EarlyView.Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung +17 more
wiley +1 more source
The interaction between tolls and capacity investment in serial and parallel transport networks [PDF]
The purpose of this paper is to compare the interaction between pricing and capacity decisions on simple serial and parallel transport networks. When individual links of the network are operated by different regional or national authorities, toll and ...
De Borger Bruno +2 more
core +3 more sources
Optimization for Express/Local Train Stop Plans on City Rapid Rail Transit Lines
Chengshi guidao jiaotong yanjiu[Objective] To minimize passenger travel time while reducing operational costs for enterprises, it is necessary to identify an optimal balance between these two competing objectives.
GUO Jingfan
doaj +1 more source
A Decision-Support Framework For Using Value Capture to Fund Public Transit: Lessons From Project-Specific Analyses [PDF]
, 2012 Local and state governments provide 75 percent of transit funds in the United States. With all levels of governments under significant fiscal stress, any new transit funding mechanism is welcome. Value capture (VC) is one such mechanism.
Mathur, Shishir, Smith, Adam
core +1 more source
Molecular Oncology, EarlyView.Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon +9 more
wiley +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers
Molecular Oncology, EarlyView.This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel +6 more
wiley +1 more source
Topical and intralesional therapies for in-transitmelanoma
Melanoma Management, 2019 This report surveys the role of topical and intralesional agents in the management of in-transit melanoma. The extent and progression of in-transit disease is highly variable and many patients can have a protracted period of locoregional control.
Michael A Henderson
doaj +1 more source
On locally graded barely transitive groups
Open Mathematics, 2013 Abstract We show that a barely transitive group is totally imprimitive if and only if it is locally graded. Moreover, we obtain the description of a barely transitive group G for the case G has a cyclic subgroup 〈x〉 which intersects non-trivially with all subgroups and for the case a point stabilizer H of G has a subgroup H
Betin Cansu, Kuzucuoğlu Mahmut
openaire +2 more sources
The interactin between tolls and capacity investment in serial and parallel transport networks [PDF]
The purpose of this paper is to compare the interaction between pricing and capacity decisions on simple serial and parallel transport networks. When individual links of the network are operated by different regional or national authorities, toll and ...
Bruno De Borger +2 more
core