Results 91 to 100 of about 100,976 (307)
Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers
Molecular Oncology, EarlyView.This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel +6 more
wiley +1 more source
Molecular Oncology, EarlyView.EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain +10 more
wiley +1 more source
Molecular Oncology, EarlyView.We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu +10 more
wiley +1 more source
Which Schubert varieties are local complete intersections? [PDF]
, 2011 International audienceWe characterize by pattern avoidance the Schubert varieties for $\mathrm{GL}_n$ which are local complete intersections (lci). For those Schubert varieties which are local complete intersections, we give an explicit minimal set of ...
Alexander Woo +4 more
core +1 more source
Certain locally nilpotent varieties of groups [PDF]
Bulletin of the Australian Mathematical Society, 2003 Let c ≥ 0, d ≥ 2 be integers and be the variety of groups in which every d-generator subgroup is nilpotent of class at most c. N.D. Gupta asked for what values of c and d is it true that is locally nilpotent? We prove that if c ≤ 2d + 2d−1 − 3 then the variety is locally nilpotent and we reduce the question of Gupta about the periodic groups in to ...
openaire +2 more sources
Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer
Molecular Oncology, EarlyView.Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley +1 more source
Scientia Agricola, 2007 The phenotypic diversity of sweet potato (Ipomoea batatas) landraces was assessed using morphological traits, verifying how this diversity is distributed among the households and settlements of the Vale do Ribeira, Brazil.
Elizabeth Ann Veasey +5 more
doaj +1 more source
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Local and most used table grape varieties in Italy
, 2014 The production and consumption of table grapes is worldwide increasing, encouraged also by the nutraceutical properties of this fresh fruit. Until the end of the XX century, almost all table grape varieties were local and/or autochthonous, while the main
DE PALMA, LAURA, Novello V.
core
Development of a Modified Dehusking Machine for Local Varieties of Coconut
Covenant Journal of Engineering Technology, 2022 Traditional dehusking of coconut is time consuming, not effective, not economical, and a difficult process, coupled with high cost of importing previously developed dehusking machines.
Olorunfemi, B. J +3 more
doaj