Results 301 to 310 of about 4,204,651 (354)

Locally Advanced Lung Cancer

Hematology/Oncology Clinics of North America, 2023
Consolidation immunotherapy after concurrent chemoradiation has improved five-year survival rates in unresectable, locally advanced lung cancer, but disease progression and treatment personalization remain challenges. New treatment approaches with concurrent immunotherapy and consolidative novel agents are being investigated and show promising efficacy
Sarah, Oh, George N, Botros, Milan, Patel, Missak, Haigentz, Eshan, Patel, Iaonnis, Kontopidis, John, Langenfeld, Matthew P, Deek, Salma K, Jabbour   +8 more
openaire   +2 more sources

MRI-guided adaptive brachytherapy in locally advanced cervical cancer (EMBRACE-I): a multicentre prospective cohort study.

The Lancet Oncology, 2021
BACKGROUND The concept of the use of MRI for image-guided adaptive brachytherapy (IGABT) in locally advanced cervical cancer was introduced 20 years ago.
R. Pötter, K. Tanderup, M. Schmid, Ina Jürgenliemk-Schulz, C. Haie-meder, L. Fokdal, A. Sturdza, P. Hoskin, U. Mahantshetty, B. Segedin, K. Bruheim, F. Huang, B. Rai, R. Cooper, E. M. van der Steen-Banasik, E. van Limbergen, B. Pieters, L. Tan, R. Nout, A. D. de Leeuw, R. Ristl, P. Petric, N. Nesvacil, K. Kirchheiner, C. Kirisits, J. Lindegaard   +25 more
semanticscholar   +1 more source

Avelumab plus standard-of-care chemoradiotherapy versus chemoradiotherapy alone in patients with locally advanced squamous cell carcinoma of the head and neck: a randomised, double-blind, placebo-controlled, multicentre, phase 3 trial.

The Lancet Oncology, 2021
BACKGROUND Chemoradiotherapy is the standard of care for unresected locally advanced squamous cell carcinoma of the head and neck. We aimed to assess if addition of avelumab (anti-PD-L1) to chemoradiotherapy could improve treatment outcomes for this ...
N. Lee, R. Ferris, A. Psyrri, R. Haddad, M. Tahara, J. Bourhis, K. Harrington, P. Chang, Jin-Ching Lin, M. Razaq, M. M. Teixeira, J. Lövey, J. Chamois, A. Rueda, Chaosu Hu, L. Dunn, M. Dvorkin, Steven De Beukelaer, D. Pavlov, H. Thurm, Ezra E. W. Cohen   +20 more
semanticscholar   +1 more source

Localized and locally advanced bladder cancer

Current Treatment Options in Oncology, 2002
Localized and locally advanced bladder cancer represents a heterogeneous spectrum of diseases with different biologic and clinical behavior. It varies with respect to invasive potential, propensity for metastases, and sensitivity to chemotherapy. Although several significant surgical advances have been made over the past 20 years in the treatment of ...
Fabio, Calabrò, Cora N, Sternberg
openaire   +2 more sources

Locally advanced breast cancer

Current Opinion in Obstetrics and Gynecology, 2006
The management of locally advanced breast cancer requires a combined-modality treatment approach involving surgery, radiotherapy and systemic therapy. In this paper, we review clinical and experimental studies in order to evaluate how basic and clinical research in locally advanced breast cancer has progressed in the past year.
Sandro, Barni, Mario, Mandalà
openaire   +2 more sources

Locally advanced esophageal cancer

Current Treatment Options in Oncology, 2002
Patients diagnosed with adenocarcinoma or squamous cell carcinoma of the esophagus should undergo computed tomography of the chest and abdomen and positron emission tomography to look for evidence of distant metastatic disease. In the absence of systemic metastases, locoregional staging should be performed with endoscopic ultrasonography and fine ...
Carol A, Sherman, Andrew T, Turrisi, Michael B, Wallace, Carolyn E, Reed   +3 more
openaire   +2 more sources

Locally advanced prostate cancer

Current Treatment Options in Oncology, 2001
Standard therapy for clinically localized prostate cancer includes radical prostatectomy, external beam radiotherapy, or transperineal interstitial brachytherapy. Patients eligible for standard therapy are those with low risk features as defined by various risk group classifications, which generally include clinical stage T1 or T2a, serum prostate ...
E A, Klein, P A, Kupelian, R, Dreicer, D, Peereboom, C, Zippe   +4 more
openaire   +2 more sources

Locally Advanced Pancreatic Cancer

Journal of Clinical Oncology, 2005
Of the 32,180 patients diagnosed with pancreatic carcinoma in the United States this year, approximately 40% will present with locally advanced disease. Radiotherapeutic approaches are often employed because these patients have unresectable tumors by virtue of local invasion into the retroperitoneal vessels in the absence of clinically detectable ...
Christopher G, Willett, Brian G, Czito, Johanna C, Bendell, David P, Ryan   +3 more
openaire   +2 more sources

Locally advanced thyroid cancer

Current Opinion in Otolaryngology & Head and Neck Surgery, 2005
The purpose of this review is to summarize existing literature with respect to locally advanced thyroid cancer and define the intricacies of preoperative evaluation, surgical management of involved sites and postoperative treatment.Locally invasive thyroid cancer is an uncommon disease process, which carries significant morbidity and mortality. Current
Kepal N, Patel, Ashok R, Shaha
openaire   +2 more sources

Locally advanced breast cancer

Oncology Reports, 1996
In vitro studies suggest p53 and bcl-2 may be important in the apoptotic response to irradiation, and that rapidly proliferating cells are more sensitive to radiotherapy. The clinical relevance of biological factors in predicting radiotherapy response was investigated in 62 patients with locally advanced breast cancer.
P, Willsher, N, Kapucuoglu, I, Ellis, S, Chan, R, Blamey, J, Robertson   +5 more
openaire   +2 more sources