Results 1 to 10 of about 8,380,026 (270)

Vismodegib and orbital excision for treating locally advanced basal cell carcinoma [PDF]

International Medical Case Reports Journal, 2018
Daniel T Hogarty,1 Nicholas G Dewhurst,1 Benjamin Burt1–4 1Bendigo Eye Clinic, Bendigo, VIC, Australia; 2Royal Victorian Eye and Ear Hospital, Melbourne, VIC, Australia; 3Cosmetic Surgery for Women, Melbourne, VIC, Australia; 4Canberra ...
Hogarty DT, Dewhurst NG, Burt B
doaj   +6 more sources

Benefit–risk assessment of sonidegib and vismodegib in the treatment of locally advanced basal cell carcinoma [PDF]

Drugs in Context, 2022
Background: Sonidegib and vismodegib are Hedgehog pathway inhibitors (HhIs) that play a relevant role in the management of locally advanced basal cell carcinoma (laBCC).
Antonio J García Ruiz, Nuria García-Agua Soler, Enrique Herrera Acosta, Iris Zalaudek, Josep Malvehy   +4 more
doaj   +4 more sources

Sonidegib in the Treatment of Locally Advanced Basal Cell Carcinoma: A Retrospective Study [PDF]

Acta Dermato-Venereologica, 2022
Sonidegib, a hedgehog pathway inhibitor, is indicated for treatment of locally advanced basal cell carcinoma, based on the results of the BOLT study. However, to date, no real-world study of sonidegib has been reported.
Florian Herms, Barouyr Baroudjian, Julie Delyon, Pauline Laly, Pauline Tetu, Celeste Lebbe, Nicole Basset-Seguin   +6 more
doaj   +4 more sources

Current Perspectives in the Treatment of Locally Advanced Basal Cell Carcinoma [PDF]

Drug Design, Development and Therapy, 2022
Neha Gupta, Emily S Ruiz Department of Dermatology, Brigham and Women’s Hospital, Harvard Medical School, Jamaica Plain, MA, USACorrespondence: Emily S RuizDepartment of Dermatology, Brigham and Women’s Hospital, Harvard Medical School, 1153 Centre ...
Gupta N, Ruiz ES
doaj   +6 more sources

Real-world assessment and treatment of locally advanced basal cell carcinoma: Findings from the RegiSONIC disease registry [PDF]

PLoS ONE, 2022
Background Limited information is available regarding real-world treatment patterns and their effectiveness and safety in patients with locally advanced basal cell carcinoma, including patients not typically represented in clinical trials. The purpose of
Aleksandar Sekulic, Simon Yoo, Ragini Kudchadkar, Julie Guillen, Gary Rogers, Anne Lynn S. Chang, Scott Guenthner, Bernard Raskin, Keith Dawson, Yong Mun, Laura Chu, Edward McKenna, Mario Lacouture   +12 more
doaj   +3 more sources

Vismodegib in neoadjuvant treatment of locally advanced basal cell carcinoma: First results of a multicenter, open-label, phase 2 trial (VISMONEO study) [PDF]

EClinicalMedicine, 2021
Background: Surgery is the primary treatment for basal cell carcinoma (BCC). In locally advanced basal cell carcinoma (laBCC), surgery may cause functional or aesthetic damage.
Nicolas Bertrand, MD, Pierre Guerreschi, MD, PhD, Nicole Basset-Seguin, MD, PhD, Philippe Saiag, MD, PhD, Alain Dupuy, MD, PhD, Sophie Dalac-Rat, MD, Véronique Dziwniel, PhD, César Depoortère, MD, Alain Duhamel, MD, PhD, Laurent Mortier, MD, PhD   +9 more
doaj   +2 more sources

Sonidegib Therapy for Locally Advanced Basal Cell Carcinoma in an Elderly Patient: A Case Report [PDF]

Clinical, Cosmetic and Investigational Dermatology
Yuyu Deng,1– 5 Pingxiu He,1– 5 Changxia Li,1– 5 Guolan Li,1– 5 Xiaohua Tao1– 5 1Dermatology Department, Dermatology Hospital of Jiangxi Province, Nanchang, Jiangxi, People’s Republic of China; 2Dermatology Department, Jiangxi Provincial Clinical Research
Deng Y, He P, Li C, Li G, Tao X
doaj   +2 more sources

The Efficacy of Sonidegib in Treating Locally Advanced Basal Cell Carcinoma Involving the Periocular Area [PDF]

Dermatology and Therapy, 2023
Introduction Basal cell carcinoma (BCC) is the most common skin malignancy in Caucasians. Globally, about 20% of BCCs involve the periocular region. The treatment of periocular BCC may be very challenging because of its proximity to the intracranial ...
Alessia Villani, Gabriella Fabbrocini, Giuseppe Micali, Luigi Fornaro, Luca Potestio, Massimiliano Scalvenzi   +5 more
doaj   +2 more sources

Survey of the impact of BOLT-trial data on oncologists’ and dermatologists’ decision-making in treating patients with locally advanced basal cell carcinoma [PDF]

Dermatology Reports
Basal cell carcinoma (BCC) is the most common malignant tumour in white populations. Multiple studies demonstrated that the aberrant activation of Hedgehog signaling is a driver of BCC development, and its blockade represents a potential therapeutic ...
Luigi Scarpato, Marco Palla, Sabino Strippoli, Luca Tagliaferri, Luca Fania, Maristella Saponara, Anna Carbone, Francesco Spagnolo, Flavia Silvestri, Paolo Antonio Ascierto   +9 more
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Management of Locally Advanced Basal Cell Carcinoma with Sonic Hedgehog Pathway Targeted Therapy: A Case Report and Discussion [PDF]

Case Reports in Dermatology
Introduction: Basal cell carcinoma (BCC) is the most common skin malignancy in the world. While most lesions are treated using surgical methods, others may present as locally advanced or metastatic disease and are not amenable to surgical therapy alone ...
Neal Ferrin, Darwin Edmond, Ryan Jones, Laurence E. McCahill   +3 more
doaj   +2 more sources