Results 21 to 30 of about 19,218 (261)

Advanced basal cell carcinoma, the hedgehog pathway, and treatment options – role of smoothened inhibitors

Biologics: Targets & Therapy, 2015
Leslie A Fecher,1,3 William H Sharfman2 1Department of Internal Medicine and Dermatology, Indiana University Health Simon Cancer Center, Indianapolis, IN, USA; 2The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, MD, USA ...
Fecher LA, Sharfman WH
doaj   +1 more source

Electrochemotherapy in the treatment of locally advanced or recurrent eyelid-periocular basal cell carcinomas [PDF]

Scientific Reports, 2019
AbstractThere is increasing evidence about the effectiveness of electrochemotherapy (ECT) in the treatment of basal cell carcinomas in the head and neck region, although its role in the management of eyelid-periocular skin tumors has to be clarified.
Erika Gabriella Kis, Eszter Baltás, Henriette Ócsai, Attila Vass, István Balázs Németh, Erika Varga, Judit Oláh, Lajos Kemény, Edit Tóth-Molnár   +8 more
openaire   +5 more sources

Surgical Debulking Modifies Notch Signaling and May Improve Vismodegib Effectiveness for Locally Advanced Basal Cell Carcinoma [PDF]

JID Innovations
Smoothened inhibitors, such as vismodegib, exhibit remarkable success in treating patients with locally advanced basal cell carcinoma (LaBCC). Yet, vismodegib efficacy is hindered by notable side effects, which often lead to treatment discontinuation and
Natella Maglakelidze, Samantha L. Gettle, Amy L. Longenecker, Allison T. Vidimos, Elizabeth M. Billingsley, Ryan P. Hobbs, Charlene Lam   +6 more
doaj   +2 more sources

A multicenter real-world analysis of first-line systemic monotherapy for locally advanced basal cell carcinoma [PDF]

JAAD Case Reports, 2023
Morgan K. Groover, BS, Neha Gupta, MD, MPH, Emily Granger, BS, Fadi Murad, MD, MPH, Vernon J. Forrester, MD, Emily J. Anstadt, MD, PhD, William Su, MD, Lauren Heusinkveld, MD, John N. Lukens, MD, Ann W. Silk, MD, MS, Allison T. Vidimos, RPh, MD, Jonathan D. Schoenfeld, MD, MPH, Shlomo A. Koyfman, MD, Emily S. Ruiz, MD, MPH   +13 more
doaj   +2 more sources

Neoadjuvant Hedgehog Inhibitors for Locally Advanced Basal Cell Carcinoma: Insights from Two Real-world Cases [PDF]

Acta Dermato-Venereologica
Paolo Antonetti, Ettore Lupi, Irene Tucceri Cimini, Maria Esposito, Maria Concetta Fargnoli   +4 more
doaj   +2 more sources

Sonidegib in Locally Advanced Basal Cell Carcinoma: A Monocentric Retrospective Experience and a Review of Published Real-Life Data. [PDF]

Cancers (Basel), 2023
Nazzaro G, Benzecry V, Mattioli MA, Denaro N, Beltramini GA, Marzano AV, Passoni E.   +6 more
europepmc   +2 more sources

Role of topical tranexamic acid in hemostasis of locally advanced basal cell carcinoma. [PDF]

JAAD Case Rep, 2016
Tranexamic acid (TXA) is a synthetic derivative of the amino acid, lysine. Conventionally used orally or intravenously, topical administration of TXA has the ability to reduce bleeding with minimal systemic absorption and, in turn, reduce the risk of systemic side effects.
Wong Y, Low JA, Chio MT.
europepmc   +3 more sources

Supplementary Figure from Frequency and Genomic Aspects of Intrinsic Resistance to Vismodegib in Locally Advanced Basal Cell Carcinoma

, 2022
Supplementary Figure from Frequency and Genomic Aspects of Intrinsic Resistance to Vismodegib in Locally Advanced Basal Cell ...
Nicole Basset-Seguin (187601), Florian Herms (15045215), Nicolas Meyer (86532), Caroline Dutriaux (15033126), Andrey A. Yurchenko (15045188), Fanny Bouquet (15045206), Brigitte Dreno (292705), Fatemeh Rajabi (691876), Sergey I. Nikolaev (14909870), Florent Grange (3569189), Caroline Robert (15032672), Lukas Flatz (251190), Meriem Ighilahriz (15045194), Oltin T. Pop (15045191), Samia Mourah (15033147), Sandrine Monestier (15045212), Nicolas Dumaz (365666), Frederic J. de Sauvage (15045218), Nicolas Poulalhon (15045200), Andrej Besse (2899043), Jerome Lambert (282171), Marc Delord (12064068), Antonio Alberti (15045203), Ariel Savina (3157380), Philippe Saiag (4219240), Max Mendez-Lopez (15045209), Nadem Soufir (108407), Maxime Battistella (15033144), Hayley J. Sharpe (15045197), Ismael Padioleau (687518), Laurent Mortier (4030046), Amir Khammari (149729)   +31 more
core   +8 more sources

Sonidegib in the Treatment of Locally Advanced Basal Cell Carcinoma

Actas Dermo-Sifiliográficas (English Edition), 2021
Sonidegib is an antagonist of the transmembrane protein Smoothened in the Hedgehog signaling pathway. It is indicated for the treatment of locally advanced basal cell carcinoma (BCC) that is not amenable to curative surgery or radiotherapy. Sonidegib's efficacy and safety were demonstrated in the phase 2 BOLT trial, where 61% (95% CI, 48-72%) of ...
Sanmartín, O, Llombart, B, Carretero Hernández, G, Flórez Menéndez, Á, Botella-Estrada, R, Herrera Ceballos, E, Puig, S   +6 more
openaire   +5 more sources

Locally advanced basal cell carcinoma of the auricle and parotid region: A case report [PDF]

Stomatološki glasnik Srbije, 2021
Skin cancers are the most common malignant tumors in general. The most significant risk factor is exposure to UV radiation. They mainly occur in the head and neck region, and the majority of about 80% are basal cell carcinomas.
Milanović Srđan, Stojanović-Rundić Suzana, Milošević Nikola, Dožić Branko, Dožić Marko   +4 more
doaj   +1 more source