Results 11 to 20 of about 5,418,708 (164)

Treatment of locally advanced rectal cancer

Surgical Oncology, 2004
Historically, locally advanced rectal cancer is known for its dismal prognosis. The treatment of locally advanced rectal cancer is subject to continuous change due to development of new and better diagnostic tools, radiotherapeutic techniques ...
Rutten, HJT, Hospers, GAP, Klaassen, RA, Nieuwenhuijzen, GAP, Wiggers, T, Martijn, H   +5 more
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Total pelvic exenteration for primary locally advanced and locally recurrent rectal cancer

European Journal of Surgical Oncology, 2007
Aims: To report the role of total pelvic exenteration in a series of locally advanced and recurrent rectal cancers. Methods: In the period 1994-2004, TPE was performed in 35 of 296 patients with primary locally advanced and recurrent rectal cancer ...
Wiggers, T., Kirkels, W. J., Nuyttens, J. J. M. E., Eggermont, A. M. M., Verhoef, C., Vermaas, M., de Wilt, J. H. W., Ferenschild, F. T. J., Marinelli, A. W. K. S.   +8 more
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The Pathophysiological effects of adjuvant preoperative chemotherapy and/or radiotherapy on patients with advanced rectal cancer [PDF]

, 2013
Introduction The modern treatment of colorectal cancer consists of surgery, with or without adjuvant pre-operative radiotherapy, chemotherapy or chemoradiotherapy (APT) for selected cases. In the United Kingdom, therapy may be given prior to surgery in
Rahmani, Samir
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Prognostic Impact of Circumferential Resection Margin in Minimally Invasive Surgery for Locally Advanced Rectal Cancer: A Multicenter Prospective Study. [PDF]

Ann Gastroenterol Surg
This multicenter prospective study provides the first Japanese evidence that circumferential resection margin positivity after minimally invasive surgery is associated with poorer long‐term outcomes in locally advanced rectal cancer. As the cohort predominantly included patients treated with upfront surgery, these findings provide important evidence to
Hamabe A, Ito M, Toda S, Suwa Y, Hasegawa S, Kotake M, Inomata M, Ueda K, Ogura A, Sugimoto K, Kimura K, Otsuka K, Noguchi T, Hida K, Hirano Y, Kawai K, Yamagishi S, Naitoh T, Takemasa I, Japan Society of Laparoscopic Colorectal Surgery.   +19 more
europepmc   +2 more sources

Radio-chemotherapy as a preoperative treatment for advanced rectal cancer. Evaluation of down-staging and morbidity [PDF]

, 2002
Background: The standard therapy for patients with clinically resectable rectal cancer is generally considered to be surgery, If the patient is diagnosed with advanced disease, postoperative radiochemotherapy (RCT) is usually recommended. In our study we
Wilkowski, R., Schaffer, Pamela Manuela, Thoma, M., Dühmke, Eckhart, Schaffer, Moshe   +4 more
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Feasibility and morbidity of combined hyperthermia and radiochemotherapy in recurrent rectal cancer - Preliminary results [PDF]

, 2003
Background: The local recurrence rate of colorectal cancer has been significantly reduced due to the use of combined radiochemotherapy. Despite this improvement regarding locally advanced tumour recurrences, the treatment strategy for pre-treated ...
Schaffer, P.M., Ertl-Wagner, Birgit, M. Schaffer, E. Dühmke, P.M. Schaffer, R.D. Issels, Pachmann, S., Abdel-Rahman, Sultan, S. Abdel-Rahman, Abdel-Rahman, S., Ertl-Wagner, B., Krych, M., Issels, Rolf-Dieter, Dühmke, E., B. Ertl-Wagner, Schaffer, Pamela Manuela, M. Krych, S. Pachmann, Schäffer, M., Issels, R.D., Dühmke, Eckhart, Schaffer, Moshe   +21 more
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Phase II trial of preoperative radiochemotherapy with concurrent bevacizumab, capecitabine and oxaliplatin in patients with locally advanced rectal cancer [PDF]

, 2013
Background: Preoperative radiochemotherapy (RCT) with 5-FU or capecitabine is the standard of care for patients with locally advanced rectal cancer (LARC). Preoperative RCT achieves pathological complete response rates (pCR) of 10-15%.
Erik Engel, Engel, Erik, Jürgen Dunst, Florian Würschmidt, Kathrin Dellas, Arnold, Dirk, Dirk Arnold, Michael Richter, Richter, Michael, Rödel, Claus, Thomas Reese, Höhler, Thomas, Thomas Höhler, Claus Rödel, Dellas, Kathrin, Reese, Thomas, Wagner, Wolfgang, Dunst, Jürgen, Würschmidt, Florian, Wolfgang Wagner   +19 more
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Prognostic and Predictive Biomarkers in Patients with Locally Advanced Rectal Cancer (LARC) Treated with Preoperative Chemoradiotherapy [PDF]

, 2022
Neoadjuvant chemoradiotherapy (CRT) is one of the standards of care in locally advanced rectal cancer (LARC). This retrospective study examines clinical, analytical, and pathological parameters collected from 77 patients with locally advanced (cT3-4 or ...
Enrique Ramalle-Gomara, Alfredo Martínez, Miriam Zorrilla-Larraga, Rubio-Mediavilla, Susana, Ramalle-Gomara, Enrique [0000-0002-6480-8397], Martínez, Alfredo [0000-0003-4882-4044], Susana Rubio-Mediavilla, Manrique-Abós, Isabel, Martínez, Alfredo, Alfonso Martín-Carnicero, Martina Alonso-Lago, Ignacio M. Larrayoz, María E. de las Heras-Dueña, Ramalle-Gomara, Enrique, de las Heras-Dueña, María E., Larrayoz, Ignacio M. [0000-0003-1629-152X], Alonso-Lago, Martina, Isabel Manrique-Abós, Larrayoz, Ignacio M., Martín-Carnicero, Alfonso, Zorrilla-Larraga, Miriam, Martín-Carnicero, Alfonso [0000-0002-8564-2875]   +21 more
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Association between pretreatment haemoglobin levels and morphometric characteristics of the tumour, response to neoadjuvant treatment and long-term outcomes in patients with locally advanced rectal cancers [PDF]

, 2013
Aim The study was carried out to investigate whether pretreatment haemoglobin (Hb) levels act as a biomar- ker in the management of patients with locally advanced rectal cancer.
Shabaan, A, Khan, AA, R. Glynne-Jones, Klonizakis, M, Glynne-Jones, R, A. A. Khan, M. Klonizakis, A. Shabaan   +7 more
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Impact of Age on Multimodality Treatment and Survival in Locally Advanced Rectal Cancer Patients [PDF]

, 2022
SIMPLE SUMMARY: The median age for diagnosing rectal cancer is 70 years. Older patients represent a heterogeneous group with varying comorbidities and have potentially higher postoperative complication risk.
Verhoeven, Rob H. A., Rutten, Harm J., Pauline A. J. Vissers, De Nes, Lindsey C. F., Valery E. P. P. Lemmens, Vissers, Pauline A J, Verhoeven, R.H.A., Rob H. A. Verhoeven, De Wilt, Johannes H W, Lemmens, Valery E P P, Vissers, Pauline A.J., Thea C. Heil, Heil, Thea C., De Nes, Lindsey C F, Lemmens, Valery E. P. P., Lemmens, V.E., Lindsey C. F. De Nes, Rutten, Harm J, Johannes H. W. De Wilt, Heil, Thea C, Harm J. Rutten, Vissers, Pauline A. J., De Wilt, Johannes H. W., Rutten, H.J., Nes, L.C.F. de, Heil, T.C., Wilt, J.H.W. de, Verhoeven, Rob H A   +27 more
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