Results 101 to 110 of about 1,652,717 (354)

Epigenetic blind spots – the role of DNA methylation dynamics in stem cell‐based models of embryogenesis

open access: yesFEBS Letters, EarlyView.
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil   +4 more
wiley   +1 more source

Mind your step! : How profiling location reveals your identity - and how you prepare for it [PDF]

open access: yes, 2006
Location-based services (LBS) are services that position your mobile phone to provide some context-based service for you. Some of these services – called ‘location tracking’ applications - need frequent updates of the current position to decide whether a
Fritsch, Lothar
core  

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

open access: yesFEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

open access: yesFEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto   +3 more
wiley   +1 more source

Broadband Ultrasonic Location Systems for Improved Indoor Positioning [PDF]

open access: yes, 2006
Ultrasonic location systems are a popular solution for the provision of fine-grained indoor positioning data. Applications include enhanced routing for wireless networks, computer-aided navigation, and location-sensitive device behavior. However, current
Mike Hazas   +3 more
core  

Measuring the Uncertainty of RFID Location Streams Based on Optimal Estimation Particle Filter

open access: yesInternational Journal of Distributed Sensor Networks, 2015
Radio Frequency Identification (RFID) technology is widely used in object tracking and tracing, especially in real-time locating system (RTLS). Due to the external and internal influence of RFID systems, a lot of redundant and uncertain location streams ...
Yaozong Liu   +3 more
doaj   +1 more source

Smart Tourism Guide Application Using Location-Based Services-Go.Travel [PDF]

open access: bronze, 2022
Wong Yit Meng   +2 more
openalex   +1 more source

Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations

open access: yesFEBS Letters, EarlyView.
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas   +6 more
wiley   +1 more source

Research and Implementation of Multi-User Location Sharing Method Based on LBS

open access: yesMATEC Web of Conferences, 2018
In order to make up for the deficiency of the lack of the location interaction between users of most LBS based applications in the market, a multi-user location sharing method(MULS) is proposed.
Leng Jing, Gong Ningjing
doaj   +1 more source

The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome

open access: yesFEBS Letters, EarlyView.
This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley   +1 more source

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