Results 181 to 190 of about 1,652,717 (354)

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Location models in the public sector [PDF]

The past four decades have witnessed an explosive growth in the field of networkbased facility location modeling. This is not at all surprising since location policy is one of the most profitable areas of applied systems analysis in regional science and ...
Daniel Serra, Vladimir Marianov
core  

Vision-based tactile sensing enhanced by microstructures and lightweight convolutional neural network. [PDF]

Microsyst Nanoeng
Shi M, Zhang Y, Guo X, Yeatman EM.
europepmc   +1 more source

Mobile location-based augmented reality applications for urban tourism storytelling

, 2017
Rui Nóbrega, João Jacob, António Coelho, Jessika Weber, João Pedro Ribeiro, Soraia Ferreira   +5 more
openalex   +2 more sources

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

A practical imaging marker to determine the posterior zone II location in premature infants. [PDF]

Int J Ophthalmol
Köse B, Kola M, Günay M, Türk A.
europepmc   +1 more source

Location-based Mobile Augmented Reality Applications - Challenges, Examples, Lessons Learned

, 2014
Philip Geiger, Marc Schickler, Rüdiger Pryss, Johannes Schobel, Manfred Reichert   +4 more
openalex   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Vaccination-Related Applications and Health Care Professionals' Observed Changes in Human Papillomavirus Vaccine Hesitancy: Cross-Sectional Survey. [PDF]

JMIR Mhealth Uhealth
Desai M, Sharma S, Fokom-Domgue J, Yu R, Chan W, Chido-Amajuoyi OG, Darkoh C, Shete S.   +7 more
europepmc   +1 more source

Implementation of Location Based Service Method in Design of Housing Location Search Applications in The City of Bengkulu

, 2023
Arevo Syahputra, Diana Diana, Yuza Reswan, Eka Sahputra   +3 more
openalex   +2 more sources