Results 51 to 60 of about 24,011,136 (289)

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

Discovering the invisible city: Location-based games for learning in smart cities [PDF]

Interaction Design and Architecture(s), 2013
In this paper we discuss how location-based mobile games can be designed for learning in modern technology enhanced public spaces. We start with the description of the design process and we identify the main challenges faced. We elaborate the case of the
Christos Sintoris, Nikoleta Yiannoutsou, Soteris Demetriou, Nikolaos Avouris   +3 more
doaj  

USAGE OF SCRATCH IN MAKING GAME-BASED MATHEMATICS LEARNING MEDIA TO IMPROVE STUDENTS' MATHEMATICAL SKILLS

Prima: Jurnal Pendidikan Matematika, 2023
This research is to see the use of Scrath as a media creation tool for Game-based mathematics learning to improve mathematical abilities, the improvement of mathematical abilities assessed is problem-solving and mathematical reasoning.
Barra P. Pradja, NISVU NANDA SAPUTRA
doaj   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

Towards Location-based Augmented Reality games

Procedia Computer Science, 2012
AbstractLocation-based games have become more popular thanks to the growth of mobile device's technology. This paper presents a framework for the development of location-based augmented reality games and wARms, an augmented-reality location- based mobile game prototype based on said framework that uses the player's real position and orientation in ...
João Tiago Pinheiro Neto Jacob, Hugo da Silva, António Coelho 0001, Rui Rodrigues 0001   +3 more
openaire   +2 more sources

Location of Firms and Outsourcing [PDF]

, 2023
We analyze the location of final goods producers under spatial competition with strategic input price determination by firm-specific input suppliers when the final goods producers undertake complete outsourcing or bi-sourcing. Under complete outsourcing,
Mukherjee, Arijit, Colombo, Stefano, Arijit Mukherjee, Stefano Colombo   +3 more
core   +1 more source

Arginine methylation as a regulatory ratchet in cancer: From substrate selection to malignant‐state stabilization

Molecular Oncology, EarlyView.
Arginine methylation can be viewed as a persistence‐prone post‐translational modification regulated by a network of PRMTs. Competitive and compensatory interactions among PRMTs can redistribute methylation across substrate pools shaped by sequence, structural, spatial, and environmental layers, reinforcing RNA‐processing, chromatin, and signaling ...
So Hyun Kwon, Ji Min Lee
wiley   +1 more source

Game (technology) based training

, 2022
S.63-72Die Betrachtung von Computerspielen in interaktiven Trainingsanwendungen eröffnet zwei grundlegende Ansätze. Der erste Aspekt ist die Nutzung von Spieletechnologien (game technology based) als Erweiterung von Virtual Reality basierten ...
Hellmich, C.
core   +1 more source

Campus Changer: A Serious Geogame for Transforming the Main Campus of the Warsaw University of Technology

Urban Planning
The goal of the article was to develop a serious geogame that allows for the activation of the Warsaw University of Technology’s (WUT) academic community’s involvement in the participatory planning process for campus revitalization and development.
Agnieszka Wendland, Kornel Samociuk, Anna Szalwa, Iker Bengoetxea Arruti, Urszula Szczepankowska-Bednarek, Jacek Wesołowski, Joanna Wnuk, Robert Olszewski   +7 more
doaj   +1 more source

Privacy through uncertainty in location-based services [PDF]

, 2013
Location-Based Services (LBS) are becoming more prevalent. While there are many benefits, there are also real privacy risks. People are unwilling to give up the benefits - but can we reduce privacy risks without giving up on LBS entirely?
Kuijpers, Bart, Othman, Walied, Shawn Merrill, Erik Buchmann, Walied Othman, Erkay Savas, Basalp, Nilguen, Biskup, Joachim, Clifton, Chris, Savaş, Erkay, Başalp, Nilgün, Buchmann, Erik, Joachim Biskup, Bart Kuijpers, Nilgun Basalp, Chris Clifton, Merrill, Shawn   +16 more
core   +1 more source