Results 41 to 50 of about 24,011,136 (289)

On Metrics for Location-Aware Games

open access: yesISPRS International Journal of Geo-Information, 2017
Metrics are important and well-known tools to measure users’ behavior in games, and gameplay in general. Particularities of location-aware games—a class of games where the player’s location plays a central role-demand specific support in metrics to ...
Luis E. Rodríguez-Pupo   +2 more
doaj   +1 more source

A Location–Time-Aware Factorization Machine Based on Fuzzy Set Theory for Game Perception

open access: yesApplied Sciences, 2022
Game user perception is of great significance for game developers and network operators for improving service quality and operational efficiency. At present, the most common approach is to use the linear model that considers only the impact of network ...
Xiaoxia Xie   +3 more
doaj   +1 more source

Undercurrents – A Computer-Based Gameplay Tool to Support Tabletop Roleplaying [PDF]

open access: yes, 2010
This paper introduces Undercurrents, a computer-based gameplay tool for providing additional communication and media streams during tabletop roleplaying sessions.
Bergström, Karl   +4 more
core  

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

open access: yesMolecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla   +9 more
wiley   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

open access: yesMolecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis   +3 more
wiley   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

open access: yesMolecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka   +9 more
wiley   +1 more source

Intelligent Location Models for Next Generation Location-based Services

open access: yes, 2007
To become truly ubiquitous, next generation location-based services (LBS) will have to rely on mobile platforms upon which multiple sensors and measurement systems have been integrated to provide continuous, three-dimensional positioning and orientation.
Winter, Stephan   +2 more
core   +4 more sources

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

open access: yesMolecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang   +9 more
wiley   +1 more source

Will in Town, ein Location-based Game

open access: yes, 2014
{"references": ["https://github.com/DHd-Verband/DHd-Abstracts-2014"]}
Gerrit Weber   +2 more
openaire   +3 more sources

BeaconPass: A Location Based APP Game for Traveler [PDF]

open access: yes, 2015
BeaconPass is a smartphone/tablet application inspired by shared problems among travelers. Following our previews research; lack of internet access, GPS inaccuracy, battery life and insufficient site-specific information, reflect on travelers getting lost and missing on their touring expectations.
Tsung-Yuan Ho   +5 more
openaire   +2 more sources

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