Results 211 to 220 of about 608,487 (295)

Deciphering and Targeting the Schwannoma‐Neuron‐Macrophage Crosstalk for the Treatment of Schwannomatosis and Associated Pain

open access: yesAdvanced Science, EarlyView.
We established patient‐derived SWN cell lines and orthotopic PDX models that recapitulate patient pain phenotypes, alongside a novel intravital DRG imaging platform to track macrophage infiltration and neuronal pain responses. Using these models, we define HMGB1–CCL2–IL‐6 signaling crosstalk driving pain and identify EGF signaling as a key regulator of
Zhenzhen Yin   +17 more
wiley   +1 more source

Emerging technologies for learning report (volume 3) [PDF]

open access: yes, 2008
De Freitas, Sara   +5 more
core  

LOCATION-BASED MOBILE GAMES FOR PLACE-MAKING

open access: yes
The main objective of this work is to understand the role that the repetitive use of location-based services -in this specific work limited to the use of LBMGs- have on people’s mobility and their interaction with place-making activities. The main questions I intend to answer in this respect are linked to change in mobility behaviors due to playing ...
openaire   +1 more source

Real‐Time Visualization of Isoform‐Specific RAF‐KRAS Interactions in Living Cells Using FRET‐BRET Hybrid Biosensors

open access: yesAdvanced Science, EarlyView.
Hybrid FRET–BRET biosensors were developed to monitor RAF–KRAS interactions in living cells. These sensors enable real‐time visualization of interaction dynamics, quantitative spectral analysis, and validation of mutation‐selective inhibitors, providing a versatile platform for probing KRAS regulation and therapeutic responses. ABSTRACT The RAS–RAF–MEK–
Jeong‐Min Go   +12 more
wiley   +1 more source

Gamification-Based Interventions in Chronic Disease Care: A Systematic Review of Randomised Controlled Trials. [PDF]

open access: yesRisk Manag Healthc Policy
Emaliyawati E   +4 more
europepmc   +1 more source

De Novo Multi‐Mechanism Antimicrobial Peptide Design via Multimodal Deep Learning

open access: yesAdvanced Science, EarlyView.
Current AI‐driven peptide discovery often overlooks complex structural data. This study presents M3‐CAD, a generative pipeline that leverages 3D voxel coloring and a massive database of over 12 000 peptides to capture nuanced physicochemical contexts.
Xiaojuan Li   +23 more
wiley   +1 more source

Effects of videos with whole-body movements on young children's geography learning. [PDF]

open access: yesNPJ Sci Learn
Mavilidi MF   +8 more
europepmc   +1 more source

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