NanoLoop: A Deep Learning Framework Leveraging Nanopore Sequencing for Chromatin Loop Prediction
Chromatin loops are central to gene regulation and 3D genome organization. Leveraging Nanopore sequencing's ability to jointly capture DNA sequence and methylation, we present NanoLoop, the first framework for genome‐wide chromatin loop prediction using Nanopore data.
Wenjie Huang +5 more
wiley +1 more source
Rational drug use in pediatric pain management: maternal attitudes and practices. [PDF]
Aydın B, Demir M, Sarı V.
europepmc +1 more source
Emerging evidence suggests that intraneuronal Aβ accumulation represents an early pathogenic event in Alzheimer's disease (AD). Using Drosophila AD model, this study shows that a nonsecreted serine protease Yip7 physically interacts with Aβ. This causes intraneuronal Aβ accumulation but surprisingly reduces the associated neurotoxicity, arguing that ...
Jingyun Su +4 more
wiley +1 more source
Differences in characteristics of two aspects of procedural learning in action video game players. [PDF]
Guo W, Tao T, Jiang J, Wang B.
europepmc +1 more source
Localized NF‐κB Inhibition Reduces Lipid Nanoparticle‐Associated Inflammation
Lipid nanoparticles (LNPs) activate NF‐κB and provoke inflammation that limits therapeutic delivery. By encapsulating selective NF‐κB inhibitors within LNPs, localized suppression of inflammatory signaling is achieved without compromising mRNA expression.
Carolann L. Espy +16 more
wiley +1 more source
Effectiveness and User Experience of Immersive Virtual Reality in Cognitive Rehabilitation for Attention-Deficit/Hyperactivity Disorder: Systematic Review. [PDF]
Single N +3 more
europepmc +1 more source
Distinct Immunomodulatory Strategies Guide Mesenchymal Stromal/Stem Cell‐Mediated Bone Regeneration
Bone regeneration by mesenchymal stem cells is strongly influenced by immune signals. This study shows that priming stem cells with regulatory immune cells or an inflammation‐resolving lipid molecule enhances bone formation through distinct immune pathways.
Salwa Suliman +5 more
wiley +1 more source
Maximizing ball movement unpredictability in association football: A Rényi entropy-based approach to optimizing event distribution randomness. [PDF]
Bandara I +5 more
europepmc +1 more source

