Delivery of Pleckstrin‐Homology Domains Suppresses PI3K/Akt Signaling and Breast Cancer Metastasis
Advanced Science, EarlyView.Current therapies curb tumor growth but not metastasis. Obscurin, a giant metastasis suppressor lost in breast cancer, restrains PI3K/Akt signaling but is impractical to restore. We deploy a mini‐obscurin, comprising the obscurin‐PH‐domain, which sequesters PI3K‐p85, potently suppressing invasion and metastasis.
Matthew Eason +12 more
wiley +1 more source
Enhancing Knee Joint Proprioception in Healthy Adults Through Exergame Training With Augmented Feedback: Randomized Controlled Pilot Trial. [PDF]
JMIR Rehabil Assist TechnolZhang Y +4 more
europepmc +1 more source
Advanced Science, EarlyView.Laser material processing is a promising technique for fabricating metal structures. Here, external electric field (EFs) assisted laser processing of metallic powders are investigated. EFs affect the melt tracks through changes in their stability and influence the grain structure in conjunction with laser intensity distribution methods. The EF‐assisted
Ankit Das +2 more
wiley +1 more source
Beyond the joystick: deep learning games for hand movement recovery. [PDF]
Front Rehabil SciAcharya V, Roy H, Kamath S, Acharya K A.
europepmc +1 more source
A comparison of single-domain and multidomain executive functions cognitive training for enhancing cognition and well-being in older adults. [PDF]
Psychol ResNguyen L, Murphy K, Andrews G, Duffy A.
europepmc +1 more source
Language-games in live mindfulness-based stress reduction: a philosophy of language analysis of participant-trainer dialogue. [PDF]
Front Psycholvan den Bold I, de Haan S, Slatman J.
europepmc +1 more source
Quantification of heading in adult football: a systematic review and evidence synthesis. [PDF]
Br J Sports MedAlexander J +5 more
europepmc +1 more source
Analyzing the impact of the automatic ball strike system in professional baseball through a case study on KBO league data. [PDF]
Sci RepLee K, Han K, Ko J.
europepmc +1 more source