Results 71 to 80 of about 1,517,047 (346)

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

open access: yesMolecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker   +16 more
wiley   +1 more source

Learning History with Location-Based Applications: An Architecture for Points of Interest in Multiple Layers

open access: yesSensors, 2020
Location-based applications (LBAs) capture the user’s physical location via satellite navigation sensors and integrate it as part of the digital application.
Samuli Laato   +5 more
doaj   +1 more source

Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting

open access: yesMolecular Oncology, EarlyView.
CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia   +9 more
wiley   +1 more source

Computing Weakest Strategies for Safety Games of Imperfect Information [PDF]

open access: yes, 2009
CEDAR (Counter Example Driven Antichain Refinement) is a new symbolic algorithm for computing weakest strategies for safety games of imperfect information. The algorithm computes a fixed point over the lattice of contravariant antichains.
Kuijper, Wouter, Pol, Jaco van de
core   +3 more sources

Molecular characterisation of human penile carcinoma and generation of paired epithelial primary cell lines

open access: yesMolecular Oncology, EarlyView.
Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad   +12 more
wiley   +1 more source

Augmented future: tracing the trajectory of location-based augmented reality gaming for the next ten years

open access: yesi-com
Location-based games are a highly technology-dependent game genre that has witnessed an exponential increase in popularity with the democratisation of smartphones as well as ubiquitous mobile data and access to satellite navigation.
Laato Samuli   +2 more
doaj   +1 more source

Path Planning Problems with Side Observations-When Colonels Play Hide-and-Seek [PDF]

open access: yes, 2019
Resource allocation games such as the famous Colonel Blotto (CB) and Hide-and-Seek (HS) games are often used to model a large variety of practical problems, but only in their one-shot versions.
Loiseau, Patrick   +3 more
core   +3 more sources

Developing evidence‐based, cost‐effective P4 cancer medicine for driving innovation in prevention, therapeutics, patient care and reducing healthcare inequalities

open access: yesMolecular Oncology, EarlyView.
The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg   +43 more
wiley   +1 more source

Comparison of video-based and sensor-based head impact exposure. [PDF]

open access: yesPLoS ONE, 2018
Previous research has sought to quantify head impact exposure using wearable kinematic sensors. However, many sensors suffer from poor accuracy in estimating impact kinematics and count, motivating the need for additional independent impact exposure ...
Calvin Kuo   +5 more
doaj   +1 more source

Client-Side Network Delay Compensation for Online Shooting Games

open access: yesIEEE Access, 2021
In online multiplayer shooting games, a long network delay can adversely impact player performance because it leads to large synchronization errors in the game information, such as location errors, between players.
Takato Motoo   +4 more
doaj   +1 more source

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