Results 41 to 50 of about 7,596,422 (242)

A Hybrid Algorithm for Location-Routing Sustainable Optimization Under Fuzzy Demand

open access: yesIEEE Access, 2022
With the globalization of the supply chain and the change of demand environment, designing an effective logistic system in the sustainable development of the supply chain becomes more critical.
Na Li, Zhifeng Fan
doaj   +1 more source

Comparing the paths of Hedgehog release in artificial and natural settings

open access: yesFEBS Letters, EarlyView.
Hh morphogens require solubilization factors to overcome their tight association with the plasma membrane and signal to distant cells, but the precise functions of these factors are controversial. Here, we use published in vivo observations as the most relevant evidence to test their suggested functions and discuss contradictions and gaps between in ...
Janna Puschmann, Kay Grobe
wiley   +1 more source

Optimization location routing problem (LRP) of humanitarian aid distribution in Sigi district using NSGA II methods

open access: yesInternational Journal of Production Management and Engineering
Disasters are events that disturb and threaten people’s lives caused by nature or/and non-natural factors as well as human factors that cause casualties and economic losses.
Serli Bombang   +2 more
doaj   +1 more source

The multifaceted roles of lysosomes in cancer

open access: yesMolecular Oncology, EarlyView.
Lysosomes support cancer cell adaptation by integrating macromolecule degradation and nutrient recycling with nutrient sensing, inter‐organelle communication and immune regulation. These interconnected functions can promote tumour growth, stress tolerance and therapy resistance, while also creating context‐dependent vulnerabilities that may be ...
Jia Li, Kevin M. Ryan
wiley   +1 more source

An outer membrane vesicle‐associated two‐track model for enterotoxigenic Bacteroides fragilis oncogenesis

open access: yesMolecular Oncology, EarlyView.
Enterotoxigenic Bacteroides fragilis is a gut bacterium linked to bowel cancer. We propose that its toxin acts along two routes: at the cell surface, cutting the adhesion protein E‐cadherin and triggering inflammation; and inside the cell, delivered by bacterial vesicles, switching on NOD1 and cancer stem cell programs.
Kangchan Choi   +2 more
wiley   +1 more source

Harmony search algorithm for location-routing problem in supply chain network design

open access: yes, 2019
The interdependence of facility location and vehicle routing has been recognized among the practitioners and researchers. The integration of these problems is more challenging in a supply chain network design problem.
Misni, F., Lee, L. S.
core   +1 more source

Using Greedy Clustering Method to Solve Capacitated Location-Routing Problem with Fuzzy Demands

open access: yesInternational Journal of Industrial Engineering and Production Research, 2016
Using Greedy Clustering Method to Solve Capacitated Location-Routing Problem with Fuzzy Demands Abstract In this paper, the capacitated location routing problem with fuzzy demands (CLRP_FD) is considered.
Yahia Zare Mehrjerdi, Ali Nadizadeh
doaj  

A hybrid matheuristic approach for the integrated location routing problem of the pineapple supply chain [PDF]

open access: yesDecision Science Letters
This paper proposes a matheuristic approach for the location-routing of industrial platforms of the pineapple supply chain problem. We have proposed a three-phase methodology to solve the considered problem. The first phase consists of obtaining
uan Sebastian Arbelaez Torres   +4 more
doaj   +1 more source

Pathways and pitfalls: a qualitative study of student experiences in biomedical science education

open access: yesFEBS Open Bio, EarlyView.
Biomedical science students from underrepresented backgrounds face barriers including financial strain, disrupted laboratory access and cultural exclusion. Peer networks provide vital support when institutional systems are difficult to navigate. To create inclusive learning environments and achieve academic success, educators should blend active, hands‐
Olivia J. Russell   +8 more
wiley   +1 more source

A Study of the Main Mathematical Models Used in Mobility, Storage, Pickup and Delivery in Urban Logistics: A Systematic Review

open access: yesSystems
This systematic review investigates the main mathematical models applied in urban logistics, focusing on routing, location and transshipment problems.
Renan Paula Ramos Moreno   +4 more
doaj   +1 more source

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