Results 51 to 60 of about 7,596,422 (242)

A Location Routing Problem with Time Windows Consideration: A Metaheuristics Approach

Applied Sciences, 2023
A substantial distribution system is achievable to attain through the simultaneous design of the location facility and route generation. This problem is generally called a location routing problem (LRP), where both strategic decision and operational ...
Meilinda Fitriani Nur Maghfiroh, Vincent F. Yu, Anak Agung Ngurah Perwira Redi, Bayu Nur Abdallah   +3 more
doaj   +1 more source

Dactolisib outperforms Rapamycin in potentiating apoptosis induced by XPO1, Bcl‐2 and Mcl‐1 blockade in preclinical glioblastoma models

FEBS Open Bio, EarlyView.
The PAM pathway and its impact on cellular metabolism. Color‐coded key symbols represent Rapamycin (R, orange, targeting mTOR) and Dactolisib (D, green, targeting PI3K/mTOR), indicating their sites of action. Created with BioRenders.com. Glioblastoma resists therapy through interconnected survival programs.
Kai Zhao, Leonie Meyer, Madita Braun, Katharina Otte, Celine Bitter, Maite Pawlik, Hartmann Raifer, Frederik Helmprobst, Axel Pagenstecher, Hans Urban, Michael C. Burger, Michael W. Ronellenfitsch, Joachim P. Steinbach, Jarmila Jedelská, Shamim Bagheri, Behrooz H. Yousefi, Pietro Di Fazio, Markus Luster, Andreas H. Mahnken, Andreas Neubauer, Andreas Burchert, Christopher Nimsky, Jörg W. Bartsch, Tillmann Rusch   +23 more
wiley   +1 more source

Ethical Foreground and Background in Adult Educator Work

New Directions for Adult and Continuing Education, EarlyView.
ABSTRACT Adult educators work in a complex ethical environment. The very act of contributing to the learning of another is fraught with moral overtones. In this paper we consider the ethical dimensions of adult educator practice by distinguishing the ethical features of the context or ‘background’ of practice from the ethical capabilities and decision ...
Steven Hodge, Sonal Nakar
wiley   +1 more source

Vehicle flow formulation for two-echelon time-constrained vehicle routing problem

Journal of Management Science and Engineering, 2019
Two-echelon routing problems, including variants such as the two-echelon vehicle routing problem (2E-VRP) and the two-echelon location routing problem (2E-LRP), involve assignment and location decisions.
Hongqi Li, Ming Bai, Yibin Zhao, Changzhi Dai   +3 more
doaj   +1 more source

Service Operation Vessels Fleet Size and Mix Location Routing for the Maintenance of an Offshore Floating Wind Farm

Journal of Marine Science and Engineering, 2023
Mixed-integer linear programming is adopted to translate the routing of service operation vessels that support the logistic aspects of the maintenance of offshore floating wind farms into mathematical language.
Lis M. R. Silva, He Li, C. Guedes Soares
doaj   +1 more source

Digital Cognitive Phenotyping for Differential Diagnosis and Monitoring in Neurological Conditions

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To assess the utility, accessibility, and equivalence to supervised scales of online cognitive assessment in older individuals with cognitive impairment. Methods Patients with Alzheimer's disease (AD, n = 31), idiopathic normal pressure hydrocephalus (iNPH, n = 26), and traumatic brain injury (TBI, n = 23) completed online cognitive ...
Martina Del Giovane, Valentina Giunchiglia, Michael C. B. David, Magdalena A. Kolanko, William R. Trender, Peter J. Hellyer, Harmeena Kaur, David J. Sharp, Christopher Carswell, Paresh A. Malhotra, Adam Hampshire   +10 more
wiley   +1 more source

BinR-LRP: A divide and conquer heuristic for large scale LRP with integrated microscopic agent-based transport simulation

Transportation Research Interdisciplinary Perspectives
The holistic optimisation of transportation systems is one of the key challenges in transportation science, because it requires the simultaneous consideration of the numerous interactions between the strategic planning level (e.g., the Facility Location ...
Elija Deineko, Carina Kehrt, Gernot Liedtke   +2 more
doaj   +1 more source

Multiobjective Location Routing Problem considering Uncertain Data after Disasters

Discrete Dynamics in Nature and Society, 2017
The relief distributions after large disasters play an important role for rescue works. After disasters there is a high degree of uncertainty, such as the demands of disaster points and the damage of paths.
Keliang Chang, Hong Zhou, Guijing Chen, Huiqin Chen   +3 more
doaj   +1 more source

Understanding the Burden of Orofacial Involvement and Patient Treatment Preferences in Systemic Sclerosis: Results From a Large International Survey

Arthritis Care &Research, EarlyView.
Objective Orofacial manifestations are significantly impactful in patients with systemic sclerosis (SSc) yet remain understudied, with no dedicated clinical guidelines to inform their management. Methods An international online survey comprised38 questions addressing orofacial manifestations of SSc, including patients’ confidence in their treating ...
Eleni Deligianni, Lee Shapiro, Deana Gibbs, Zsuzsanna H. McMahan, Michael Hughes   +4 more
wiley   +1 more source

Exact algorithms for the clustered vehicle routing problem [PDF]

, 2014
This study presents new exact algorithms for the Clustered Vehicle Routing Problem (CluVRP). The CluVRP is a generalization of the Capacitated Vehicle Routing Problem (CVRP), in which the customers are grouped into clusters.
Vigo, Daniele, Güneş Erdoğan, Erdogan, G., Erdogan, Gunes, Battarra, Maria, Maria Battarra, Battarra, M., Vigo, D., Battarra, Maria; id_orcid, Erdogan, G; id_orcid   +9 more
core   +1 more source