Results 21 to 30 of about 102,027 (262)

Mode of action and functional significance of 7alpha-hydroxypregnenolone stimulating locomotor activity

Frontiers in Endocrinology, 2011
Previous studies over the past two decades have demonstrated that the brain and other nervous systems possess key steroidogenic enzymes and produces pregnenolone and other various neurosteroids in vertebrates in general.
Shogo eHaraguchi, Masahiro eMatsunaga, Hubert eVaudry, Kazuyoshi eTsutsui   +3 more
doaj   +1 more source

Glutamatergic mechanisms for speed control and network operation in the rodent locomotor CPG

Frontiers in Neural Circuits, 2010
Locomotion is a fundamental motor act that, to a large degree, is controlled by central pattern generating (CPG) networks in the spinal cord. Glutamate is thought to be responsible for most of the excitatory input to and the excitatory activity within ...
Adolfo E Talpalar, Ole Kiehn
doaj   +1 more source

Behavioral Characterization of the Effects of Cannabis Smoke and Anandamide in Rats. [PDF]

PLoS ONE, 2016
Cannabis is the most widely used illicit drug in the world. Delta-9-tetrahydrocannabinol (Δ9-THC) is the main psychoactive component of cannabis and its effects have been well-studied.
Adriaan W Bruijnzeel, Xiaoli Qi, Lidia V Guzhva, Shannon Wall, Jie V Deng, Mark S Gold, Marcelo Febo, Barry Setlow   +7 more
doaj   +1 more source

Activation of neurotensin receptor type 1 attenuates locomotor activity [PDF]

Neuropharmacology, 2014
Intracerebroventricular administration of neurotensin (NT) suppresses locomotor activity. However, the brain regions that mediate the locomotor depressant effect of NT and receptor subtype-specific mechanisms involved are unclear. Using a brain-penetrating, selective NT receptor type 1 (NTS1) agonist PD149163, we investigated the effect of systemic and
Chelsea A. Vadnie, David J. Hinton, Sun Choi, YuBin Choi, Christina L. Ruby, Alfredo Oliveros, Miguel L. Prieto, Jun Hyun Park, Doo-Sup Choi   +8 more
openaire   +2 more sources

Exendin-4 decreases amphetamine-induced locomotor activity [PDF]

Physiology & Behavior, 2012
Glucagon-like peptide-1 (GLP-1) is released in response to nutrient ingestion and is a regulator of energy metabolism and consummatory behaviors through both peripheral and central mechanisms. The GLP-1 receptor (GLP-1R) is widely distributed in the central nervous system, however little is known about how GLP-1Rs regulate ambulatory behavior.
Kevin, Erreger, Adeola R, Davis, Amanda M, Poe, Nigel H, Greig, Gregg D, Stanwood, Aurelio, Galli   +5 more
openaire   +2 more sources

Contrasting effects of leptin on food anticipatory and total locomotor activity. [PDF]

PLoS ONE, 2011
Obese, leptin deficient obob mice have profoundly decreased activity and increased food seeking behavior. The decreased activity has been attributed to obesity. In mice, we tested the hypothesis that leptin increases total locomotor activity but inhibits
Ana C Ribeiro, Giovanni Ceccarini, Christophe Dupré, Jeffrey M Friedman, Donald W Pfaff, Allyn L Mark   +5 more
doaj   +1 more source

Zebrafish (Danio rerio) embryo-larvae locomotor activity data analysis: Evaluating anxiolytic effects of the antidepressant compound citalopram

Data in Brief, 2019
Newly fertilized zebrafish (Danio rerio) embryos were exposed to increasing concentrations of the selective serotonin reuptake inhibitor (SSRI) citalopram from fertilization until six days post-fertilization (dpf).
Johannes Pohl
doaj   +1 more source

The role and implications of mammalian cellular circadian entrainment

FEBS Letters, EarlyView.
At their most fundamental level, mammalian circadian rhythms occur inside every individual cell. To tell the correct time, cells must align (or ‘entrain’) their circadian rhythm to the external environment. In this review, we highlight how cells entrain to the major circadian cues of light, feeding and temperature, and the implications this has for our
Priya Crosby
wiley   +1 more source

Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing

FEBS Letters, EarlyView.
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley   +1 more source

Integration of circadian and hypoxia signaling via non‐canonical heterodimerization

FEBS Letters, EarlyView.
CLOCK, BMAL1, and HIFs are basic helix‐loop‐helix and Per‐Arnt‐Sim domain (bHLH‐PAS) proteins, which function as transcription factors. bHLH‐PAS proteins are designated in two classes. Many class I proteins are regulated by environmental signals via their PAS domains, but such signals have not been identified for all.
Sicong Wang, Katja A. Lamia
wiley   +1 more source