Results 241 to 250 of about 1,870,567 (303)

A pH‐Responsive fluorescence lifetime probe reveals GOT1 phase separation in cellular anti‐senescence

Smart Molecules, EarlyView.
Acidic pH triggers GOT1 phase separation via IDR1, recruiting ME1 to form ROS‐scavenging condensates that combat senescence, revealed by a FLIM‐based pH probe. Abstract Cellular senescence involves progressive acidification, but how cells sense and adapt to this pH shift remains unclear.
Ziyue Chen, Jiaqi Li, Yan Bao, Mengmeng Wang, Haoyan Chen, Mingjiong Zhang, Lina Ding, Shuangshuang Wu, Baoxing Shen   +8 more
wiley   +1 more source

A streamlined hybrid-capture and genome-wide multi-omic platform for highly sensitive ctDNA minimal residual disease monitoring. [PDF]

J Liq Biopsy
Nguyen T, Nguyen Hoang VA, Huynh C, Nguyen V, Le SH, Trac QT, Nguyen Hoang TP, Dao NA, Nguyen MTB, Tran NH, Phan DM, Giang H, Nguyen HN, Tu LN.   +13 more
europepmc   +1 more source

A dual‐responsive fluorescent probe for imaging viscosity and polarity in nonalcoholic fatty liver disease

Smart Molecules, EarlyView.
We developed a BODIPY‐based fluorescent probe with dual responsiveness to viscosity and polarity, enabling sensitive and precise imaging of non‐alcoholic fatty liver disease. Abstract Viscosity and polarity are critical physiological parameters implicated in the onset and progression of nonalcoholic fatty liver disease (NAFLD).
Di Zhao, Zhizhong Wang, Ke Xu, Yuntai Liu, Di Wu, Ting Jiang, Haonan Gao, Chengmei Xiao, Debin Zheng, Kai Wang, Wenhao Zhai   +10 more
wiley   +1 more source

Analytical and Clinical Evaluation of a Fully Automated Direct-from-Whole-Blood Multiplex PCR Assay Using Large-Volume Reverse Elution for Rapid Bloodstream Infection Diagnosis. [PDF]

Antibiotics (Basel)
Tai CS, Chung HY, Lin TH, Chang CK, Perng CL, Shang HS, Jian MJ.   +6 more
europepmc   +1 more source

Gold‐Modified Mesoporous Carbon Enables Serum Metabolic Fingerprinting for Papillary Thyroid Carcinoma Diagnosis

Small Methods, EarlyView.
A novel MCHS‑Au‑LA substrate is developed for carbon‑gold nanostructure‐initiator mass spectrometry (C‑Au‑NIMS), which acquires metabolic fingerprints of serum samples from papillary thyroid carcinoma (PTC), benign thyroid nodules (BTN), and healthy controls (HC).
Wanwan Yi, Yida Huang, Jiayou Feng, Xiaowen Zhang, Yuheng Zhu, Kun Qian, Chang Lei, Zhongwei Lv, Chengzhong Yu   +8 more
wiley   +1 more source

Uncovering Hidden Genetic Diversity in Ancient Palestinian Olive Rootstocks and Insights into Levantine Domestication. [PDF]

Plants (Basel)
Alomary A, Mariotti R, Alabdallah O, Cruciani L, Bashir MA, Abueid MM, Alkowni R, Casciani S, Mousavi S.   +8 more
europepmc   +1 more source

Role of Oral Glucagon-Like Peptide-1 Receptor Agonists in Weight Management for Individuals With Overweight or Obesity Without Diabetes: A Network Meta-Analysis of Randomized Controlled Trials. [PDF]

Obes Sci Pract
Kamrul-Hasan ABM, Ashraf H, Nagendra L, Khalil I, Chatterjee S, Dutta D, Haq T, Alanazi MA, Pappachan JM.   +8 more
europepmc   +1 more source

An integrated genetic approach prioritizes closely linked candidate genes underlying an open-field behavior QTL on chicken chromosome 1. [PDF]

Poult Sci
Ido A, Ochiai T, Terashima M, Ishikawa A.   +3 more
europepmc   +1 more source

A Sustainable Hybrid (NH₄)₂SO₄-Driven SALLE-Fluorimetric On-Off Integrated Platform for the Determination of Cinacalcet HCl: A Calcium Receptors Sensing Drug in Different Matrices. [PDF]

Luminescence
Hamad AA, Ali MAM, Chaudhary AA, Al-Farhan BS, Saleh SF, Ibrahim AMM, Mawkili W, Ghazwani NA.   +7 more
europepmc   +1 more source