Results 261 to 270 of about 33,686 (303)

Effects of Misspecifying Genetic Parameters in Lod Score Analysis

Biometrics, 1986
The lod score method is widely used to test linkage and to estimate the recombination fraction between a disease locus and a marker locus. The parameters (gene frequency, penetrance, and degree of dominance) are assumed to be known at each locus. This condition may not be fulfilled at the disease locus.
F Clerget-Darpoux
exaly   +3 more sources

Lod score Redivivus

Nature, 1988
N E Morton
exaly   +3 more sources

Lod score or log-likelihood?

Nature, 1988
A W F Edwards
exaly   +3 more sources

9 Extension of the lod score: The mod score

Advances in Genetics, 2001
F Clerget-Darpoux
exaly   +2 more sources

Lod Score

2006
exaly   +3 more sources

8 The lod score method

Advances in Genetics, 2001
John P Rice, Nancy L Saccone
exaly   +2 more sources

Distribution of lod Scores in Oligogenic Linkage Analysis

Genetic Epidemiology, 2001
In variance component oligogenic linkage analysis it can happen that the residual additive genetic variance bounds to zero when estimating the effect of the ith quantitative trait locus. Using quantitative trait Q1 from the Genetic Analysis Workshop 12 simulated general population data, we compare the observed lod scores from oli‐gogenic linkage ...
J T, Williams, K E, North, L J, Martin, A G, Comuzzie, H H, Göring, J, Blangero   +5 more
openaire   +2 more sources

Lod Score Curves for Phase-Unknown Matings

Human Heredity, 1996
For a phase-unknown nuclear family, we show that the likelihood and lod score are unimodal, and we describe conditions under which the maximum occurs at recombination fraction theta = 0, theta = 1/2, and 0 < theta < 1/2. These simply stated necessary and sufficient conditions seem to have escaped the notice of previous statistical geneticists.
T, Hulbert-Shearon, M, Boehnke, K, Lange
openaire   +2 more sources

Lods, wrods, and mods: The interpretation of lod scores calculated under different models

Genetic Epidemiology, 1994
AbstractIn this paper we examine the relationships among classical lod scores, “wrod” scores (lod scores calculated under the wrong genetic model), and “mod” scores (lod scores maximized over genetic model parameters). We compare the behavior of these scores when the state of nature is linkage to their behavior when the state of nature is no linkage ...
S E, Hodge, R C, Elston
openaire   +2 more sources

Interpretation of LOD scores with a set of marker loci

Genetic Epidemiology, 1984
AbstractThe problem discussed is that of interpreting LOD scores when multiple markers are tested for linkage with a particular disease locus. Provided the tests are based on independent segregations, both the maximum and the average LOD can be translated into a score that would have the same significance level were it the result of a single test.
E. A. Thompson, Walter E. Nance
openaire   +2 more sources