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Effect of Heterogeneity and Assumed Mode of Inheritance on Lod Scores
American Journal of Medical Genetics, Part A, 1992AbstractHeterogeneity is a major factor in many common, complex diseases and can confound linkage analysis. Using computer‐simulated heterogeneous data we tested what effect unlinked families have on a linkage analysis when heterogeneity is not taken into account.
Martina Durner +2 more
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Efficiency of Lod Scores for Representing Multiple Locus Linkage Data
Genetic Epidemiology, 1985AbstractThe problem of compact, fully efficient representation of multilocus data has not yet been solved. Lod scores can be used to map multilocus data, but because of certain statistical problems, this method loses some information. However, simulation studies show that for distances less than 10 or 20 cMo, where there is little danger of huge ...
C J Maclean, N E Morton, D C Rao
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The Power to Detect Linkage in Complex Disease by Means of Simple LOD-Score Analyses
American Journal of Human Genetics, 1998 SummaryMaximum-likelihood analysis (via LOD score) provides the most powerful method for finding linkage when the mode of inheritance (MOI) is known. However, because one must assume an MOI, the application of LOD-score analysis to complex disease has ...
Susan E Hodge +2 more
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Posterior probability of linkage and maximal lod score
Annals of Human Genetics, 1995SummaryTo detect linkage between a trait and a marker, Morton (1955) proposed to calculate the lod score z(θ1) at a given value θ1 of the recombination fraction. If z(θ1) reaches +3 then linkage is concluded. However, in practice, lod scores are calculated for different values of the recombination fraction between 0 and 0·5 and the test is based on the
E, Génin +2 more
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On the lod score method in linkage analysis
Annals of Human Genetics, 1984SummaryGenetic epidemiology deals with the interaction of environmental and genetic determinants in common diseases. Linkage analysis is an important branch of this field. The current practice of claiming linkage between two genetic loci when the maximum lod score z(θ) exceeds 3 has not received theoretical justification, whether considered as a ...
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Effects of Misspecifying Genetic Parameters in Lod Score Analysis
Biometrics, 1986The lod score method is widely used to test linkage and to estimate the recombination fraction between a disease locus and a marker locus. The parameters (gene frequency, penetrance, and degree of dominance) are assumed to be known at each locus. This condition may not be fulfilled at the disease locus.
F, Clerget-Darpoux +2 more
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Advances in genetics, 2001
The lod score method originated in a seminal article by Newton Morton in 1955. The method is broadly concerned with issues of power and the posterior probability of linkage, ensuring that a reported linkage has a high probability of being a true linkage.
J P, Rice, N L, Saccone, J, Corbett
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The lod score method originated in a seminal article by Newton Morton in 1955. The method is broadly concerned with issues of power and the posterior probability of linkage, ensuring that a reported linkage has a high probability of being a true linkage.
J P, Rice, N L, Saccone, J, Corbett
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MCMC Multilocus Lod Scores: Application of a New Approach
Human Heredity, 2005On extended pedigrees with extensive missing data, the calculation of multilocus likelihoods for linkage analysis is often beyond the computational bounds of exact methods. Growing interest therefore surrounds the implementation of Monte Carlo estimation methods.
Andrew W, George +2 more
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Inferring mode of inheritance by comparison of lod scores
American Journal of Medical Genetics, 1989AbstractOne usually must assume a mode of inheritance when using lod scores for linkage analysis. In this study, we asked the question, “If one assumed mode of inheritance in a linkage analysis gives a higher lod score than another, does that indicate that the mode of inheritance that led to the higher lod score is more ‘correct’ than the other?”We ...
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