Results 271 to 280 of about 33,686 (303)

Effect of heterogeneity and assumed mode of inheritance on lod scores

American Journal of Medical Genetics, 1992
AbstractHeterogeneity is a major factor in many common, complex diseases and can confound linkage analysis. Using computer‐simulated heterogeneous data we tested what effect unlinked families have on a linkage analysis when heterogeneity is not taken into account.
M, Durner, D A, Greenberg
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The lod score method.

Advances in genetics, 2001
The lod score method originated in a seminal article by Newton Morton in 1955. The method is broadly concerned with issues of power and the posterior probability of linkage, ensuring that a reported linkage has a high probability of being a true linkage.
J P, Rice, N L, Saccone, J, Corbett
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MCMC Multilocus Lod Scores: Application of a New Approach

Human Heredity, 2005
On extended pedigrees with extensive missing data, the calculation of multilocus likelihoods for linkage analysis is often beyond the computational bounds of exact methods. Growing interest therefore surrounds the implementation of Monte Carlo estimation methods.
Andrew W, George, Ellen M, Wijsman, Elizabeth A, Thompson   +2 more
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Inferring mode of inheritance by comparison of lod scores

American Journal of Medical Genetics, 1989
AbstractOne usually must assume a mode of inheritance when using lod scores for linkage analysis. In this study, we asked the question, “If one assumed mode of inheritance in a linkage analysis gives a higher lod score than another, does that indicate that the mode of inheritance that led to the higher lod score is more ‘correct’ than the other?”We ...
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Efficiency of lod scores for representing multiple locus linkage data

Genetic Epidemiology, 1985
AbstractThe problem of compact, fully efficient representation of multilocus data has not yet been solved. Lod scores can be used to map multilocus data, but because of certain statistical problems, this method loses some information. However, simulation studies show that for distances less than 10 or 20 cMo, where there is little danger of huge ...
C. J. Maclean, N. E. Morton, R. Lew, D. C. Rao   +3 more
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The use of lod scores for the determination of the order of loci on a chromosome

Annals of Human Genetics, 1975
A method is given for calculating the probabilities of the possible gene orders for a group of syntenic loci using lod scores calculated for each pair of loci in the group. Applying it, we find the most probable gene order for the five loci on chromosome 1 to be PGM1; Rh; PGD; PEP-C; Fy.
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Extension of the lod score: the mod score.

Advances in genetics, 2001
In 1955 Morton proposed the lod score method both for testing linkage between loci and for estimating the recombination fraction between them. If a disease is controlled by a gene at one of these loci, the lod score computation requires the prior specification of an underlying model that assigns the probabilities of genotypes from the observed ...
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Asymptotic distribution of the lod score for familial data.

Proceedings of the National Science Council, Republic of China. Part B, Life sciences, 1989
Using a linkage model with mixed parental mating types between a trait locus and a marker locus the asymptotic null distribution of the statistic U = 2ln(10)Z(theta) was stimulated and compared to the chi square type distribution function 1/2 + 1/2 Pr [chi 2(1) less than mu].
J J, Tai, C L, Chen
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Sensitivity of lod scores to changes in diagnostic status.

American journal of human genetics, 1992
This paper investigates effects on lod scores when one individual in a data set changes diagnostic or recombinant status. First we examine the situation in which a single offspring in a nuclear family changes status. The nuclear-family situation, in addition to being of interest in its own right, also has general theoretical importance, since nuclear ...
S E, Hodge, D A, Greenberg
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Major strengths and weaknesses of the lod score method.

Advances in genetics, 2001
Strengths and weaknesses of the lod score method for human genetic linkage analysis are discussed. The main weakness is its requirement for the specification of a detailed inheritance model for the trait. Various strengths are identified. For example, the lod score (likelihood) method has optimality properties when the trait to be studied is known to ...
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