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The use of lod scores for the determination of the order of loci on a chromosome
Annals of Human Genetics, 1975A method is given for calculating the probabilities of the possible gene orders for a group of syntenic loci using lod scores calculated for each pair of loci in the group. Applying it, we find the most probable gene order for the five loci on chromosome 1 to be PGM1; Rh; PGD; PEP-C; Fy.
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Extension of the lod score: the mod score.
Advances in genetics, 2001In 1955 Morton proposed the lod score method both for testing linkage between loci and for estimating the recombination fraction between them. If a disease is controlled by a gene at one of these loci, the lod score computation requires the prior specification of an underlying model that assigns the probabilities of genotypes from the observed ...
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Asymptotic distribution of the lod score for familial data.
Proceedings of the National Science Council, Republic of China. Part B, Life sciences, 1989Using a linkage model with mixed parental mating types between a trait locus and a marker locus the asymptotic null distribution of the statistic U = 2ln(10)Z(theta) was stimulated and compared to the chi square type distribution function 1/2 + 1/2 Pr [chi 2(1) less than mu].
J J, Tai, C L, Chen
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Sensitivity of lod scores to changes in diagnostic status.
American journal of human genetics, 1992This paper investigates effects on lod scores when one individual in a data set changes diagnostic or recombinant status. First we examine the situation in which a single offspring in a nuclear family changes status. The nuclear-family situation, in addition to being of interest in its own right, also has general theoretical importance, since nuclear ...
S E, Hodge, D A, Greenberg
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Major strengths and weaknesses of the lod score method.
Advances in genetics, 2001Strengths and weaknesses of the lod score method for human genetic linkage analysis are discussed. The main weakness is its requirement for the specification of a detailed inheritance model for the trait. Various strengths are identified. For example, the lod score (likelihood) method has optimality properties when the trait to be studied is known to ...
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Further Evidence for the Increased Power of LOD Scores Compared With Nonparametric Methods
American Journal of Human Genetics, 1999Veronica J Vieland +2 more
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Allele-Sharing Models: LOD Scores and Accurate Linkage Tests
American Journal of Human Genetics, 1997Augustine Kong, Nancy J Cox
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