Results 61 to 70 of about 4,191,932 (286)
Arithmetic properties of the Ramanujan function
, 2006 We study some arithmetic properties of the Ramanujan function $\tau(n)$, such as the largest prime divisor $P(\tau(n))$ and the number of distinct prime divisors $\omega(\tau(n))$ of $\tau(n)$ for various sequences of $n$.
Luca, Florian, Shparlinski, Igor E
core +1 more source
Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source
Molecular Oncology, EarlyView.We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto +8 more
wiley +1 more source
On the Complexity of Making a Distinguished Vertex Minimum or Maximum Degree by Vertex Deletion [PDF]
, 2014 In this paper, we investigate the approximability of two node deletion problems. Given a vertex weighted graph $G=(V,E)$ and a specified, or "distinguished" vertex $p \in V$, MDD(min) is the problem of finding a minimum weight vertex set $S \subseteq V ...
Devi, N Safina +2 more
core
Improved Online Algorithm for Weighted Flow Time
, 2018 We discuss one of the most fundamental scheduling problem of processing jobs on a single machine to minimize the weighted flow time (weighted response time).
Azar, Yossi, Touitou, Noam
core +1 more source
Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source
Next‐generation proteomics improves lung cancer risk prediction
Molecular Oncology, EarlyView.This is one of very few studies that used prediagnostic blood samples from participants of two large population‐based cohorts. We identified, evaluated, and validated an innovative protein marker model that outperformed an established risk prediction model and criteria employed by low‐dose computed tomography in lung cancer screening trials.
Megha Bhardwaj +4 more
wiley +1 more source
QSAR STUDY ON SEROTONIN DERIVATIVES
Studia Universitatis Babes-Bolyai Chemia, 2015 A set of 40 serotonin derivatives, downloaded from the PubChem database, was submitted to a QSAR study, following Diudea’s algorithm, in the frame of a hypermolecule, which mimics the alignment of drug molecules to the biological receptors.
Sara ERSALI, Mircea V. DIUDEA
doaj
Semiparametric estimation for a class of time-inhomogenous diffusion processes [PDF]
, 2009 Copyright @ 2009 Institute of Statistical Science, Academia SinicaWe develop two likelihood-based approaches to semiparametrically estimate a class of time-inhomogeneous diffusion processes: log penalized splines (P-splines) and the local log-linear ...
Li, M, Wang, H, Yu, K, Yu, Y
core
Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib
Molecular Oncology, EarlyView.WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute +17 more
wiley +1 more source