Results 61 to 70 of about 5,559,638 (318)

Improving PARP inhibitor efficacy in bladder cancer without genetic BRCAness by combination with PLX51107

open access: yesMolecular Oncology, EarlyView.
Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz   +15 more
wiley   +1 more source

Impact of long-range interactions on the disordered vortex lattice

open access: yes, 2003
The interaction between the vortex lines in a type-II superconductor is mediated by currents. In the absence of transverse screening this interaction is long-ranged, stiffening up the vortex lattice as expressed by the dispersive elastic moduli.
A.I. Larkin   +38 more
core   +1 more source

LINC01116, a hypoxia‐lncRNA marker of pathological lymphangiogenesis and poor prognosis in lung adenocarcinoma

open access: yesMolecular Oncology, EarlyView.
The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola   +12 more
wiley   +1 more source

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

open access: yesMolecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta   +10 more
wiley   +1 more source

A separation of some Seiffert-type means by power means

open access: yesJournal of Numerical Analysis and Approximation Theory, 2012
Consider the identric mean \(\mathcal{I}\), the logarithmic mean \(\mathcal{L,}\) two trigonometric means defined by H. J. Seiffert and denoted by \(\mathcal{P}\) and \(\mathcal{T,}\) and the hyperbolic mean \(\mathcal{M}\) defined by E.
Iulia Costin, Gheorghe Toader
doaj   +2 more sources

Stolarsky Means in Many Variables

open access: yesMathematics, 2020
We give in this article two possible explicit extensions of Stolarsky means to the multi-variable case. They attain all main properties of Stolarsky means and coincide with them in the case of two variables.
Slavko Simić, Bandar Bin-Mohsin
doaj   +1 more source

Emergy-based indicators of the environmental impacts and driving forces of non-point source pollution from crop production in China

open access: yesEcological Indicators, 2021
Sustainable crop production is a significant challenge in China. To achieve this goal, it is necessary to evaluate environmental impacts related to the sustainable development of crop production by integrating scientific and practical indicators ...
Zuoxi Liu   +11 more
doaj   +1 more source

On Trapezoid Inequality Via a Grüss Type Result and Applications [PDF]

open access: yes, 1999
In this paper, we point out a Grüss type inequality and apply it for special means (logarithmic mean, identric mean, etc...
Dragomir, Sever S, McAndrew, Alasdair
core  

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

open access: yesMolecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova   +25 more
wiley   +1 more source

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