Results 231 to 240 of about 5,412 (286)

Cryo‐EM Structure Guided Engineering of Botulinum Neurotoxin A With Advanced Receptor Binding Affinity and Therapeutical Benefits

open access: yesAdvanced Science, Volume 13, Issue 33, 15 June 2026.
The butterfly unfolded wing in an open form structure of botulinum neurotoxin type A (BoNT/A) at physiological‐state was confirmed at 2.85 Å resolution by cryo‐electron microscopy (cryo‐EM). Structure‐guided protein engineering significantly enhanced the receptor‐binding affinity, therapeutic efficacy, and safety of the engineered toxin variants ...
Wenrui Wang   +16 more
wiley   +1 more source

Amplification through local critical behavior in the mammalian cochlea. [PDF]

open access: yesProc Natl Acad Sci U S A
Alonso RG   +3 more
europepmc   +1 more source

SKOOTS: Skeleton‐Oriented Object Segmentation for Mitochondria in High‐Resolution Cochlear EM Datasets

open access: yesAdvanced Science, Volume 13, Issue 32, 9 June 2026.
Skeleton‐oriented object segmentation (SKOOTS) introduces a new strategy for 3D mitochondrial instance segmentation by predicting explicit skeletons rather than relying on boundary cues. This approach enables robust analysis of densely packed organelles in large FIB‐SEM datasets.
Christopher J. Buswinka   +3 more
wiley   +1 more source

Multi-Modal Joint Pulsed Eddy Current Sensor Signal Denoising Method Integrating Inductive Disturbance Mechanism. [PDF]

open access: yesSensors (Basel)
Zuo Y   +11 more
europepmc   +1 more source

Gecko‐Like Multi‐Directional High‐Power Magneto–Mechano–Electric Energy Harvesters for Self‐Powered, Hundred‐Meter‐Scale LoRa Communication

open access: yesAdvanced Science, Volume 13, Issue 32, 9 June 2026.
Gecko like multi directional high power magneto mechano electric energy harvester (MME EH) for self powered, hundred meter scale LoRa communication. Inspired by the symmetric and flexible limb motion of geckos, the biomimetic harvester enables coordinated bending twisting responses to weak, low frequency (50/60 Hz) stray magnetic fields from power ...
Shitong Fang   +13 more
wiley   +1 more source

A misaligned protostellar disk fed by gas streamers in a barred spiral-like massive dense core. [PDF]

open access: yesSci Adv
Mai X   +44 more
europepmc   +1 more source

Developing Micro/Nanostructured Fluidic Mixing Technology for Biomedical Applications

open access: yesAdvanced Science, Volume 13, Issue 33, 15 June 2026.
This review critically evaluates how micro/nanostructured mixing technologies are redefining biomedical research. By synergizing fundamental analysis, numerical modeling, structural design, and external field manipulation, these systems attain unprecedented control over mass transport.
Junkai Wang   +3 more
wiley   +1 more source

Vulnerability of the locus coeruleus–entorhinal cortex white matter tract in autosomal dominant Alzheimer's disease

open access: yesAlzheimer's &Dementia, Volume 22, Issue 6, June 2026.
Abstract INTRODUCTION Locus coeruleus (LC) structural integrity declines early in sporadic and autosomal dominant Alzheimer's disease (AD). We examined LC–entorhinal cortex (LC‐EC) tract integrity and its association with amyloid and tau pathology and memory in autosomal dominant AD (ADAD).
Elouise A. Koops   +11 more
wiley   +1 more source

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