Results 71 to 80 of about 44,428 (278)

Promotion of DFU Wound Healing via BRG1–COL16A1 Axis in Fibroblasts

Advanced Science, EarlyView.
In normal wound healing, transcription factor BRG1 is upregulated and binds the COL16A1 promoter to enhance its expression, promoting fibroblast proliferation, migration, contraction, extracellular matrix deposition, and granulation tissue formation, thus accelerating wound closure.
Penghui Wang, Jiaming Sun, Ying Wang, Bichen Ren, Yuxin Liu, Yunhan Liu, Liang Chen, Lu Yu, Tao Dai, Li Yu, Zhihui Dong   +10 more
wiley   +1 more source

A novel logarithmic spiral design for proximal interphalangeal joint arthroplasty

Scientific Reports
This study evaluated a novel implant for proximal interphalangeal (PIP) joint arthroplasty that we designed according to the principles of a logarithmic spiral. The design addresses the limitations of current implants that poorly replicate natural finger
Hitoshi Hirata, Shigeru Kurimoto, Hidemasa Yoneda, Yasuharu Koike, Renita Sirisena, Shingo Shimoda   +5 more
doaj   +1 more source

Spiral cracks in drying precipitates

, 2002
We investigate the formation of spiral crack patterns during the desiccation of thin layers of precipitates in contact with a substrate. This symmetry-breaking fracturing mode is found to arise naturally not from torsion forces, but from a propagating ...
A. E. Tucker, A. E. Tucker, A. E. Tucker, A. Groisman, A. T. Skjeltorp, A. Yuse, B. Cotterell, B. K. Chakrabati, B. Lawn, D'Arcy Thompson, D. Hull, D. Hull, J. K. Gillham, K. A. Shorlin, K.-t. Leung, K.-t. Leung, K.-t. Leung, O. M. Bostman, P. Frick, T. Bai, Z. C. Xia   +20 more
core   +1 more source

Cryo‐EM Structure Guided Engineering of Botulinum Neurotoxin A With Advanced Receptor Binding Affinity and Therapeutical Benefits

Advanced Science, EarlyView.
The butterfly unfolded wing in an open form structure of botulinum neurotoxin type A (BoNT/A) at physiological‐state was confirmed at 2.85 Å resolution by cryo‐electron microscopy (cryo‐EM). Structure‐guided protein engineering significantly enhanced the receptor‐binding affinity, therapeutic efficacy, and safety of the engineered toxin variants ...
Wenrui Wang, Zhaxi Zerang, Linjin You, Ziye Liu, Rong Nie, Fuwei Qi, Fenfen Gao, Chengmu Zhao, Wantong Ma, Jinghan He, Xiaoru Wang, Shanquan Wu, Bo Liu, Xinyao Liu, Dongsheng Lei, Dejuan Zhi, Dongsheng Wang   +16 more
wiley   +1 more source

Dynamics of Vortex Pair in Radial Flow

, 2008
The problem of vortex pair motion in two-dimensional plane radial flow is solved. Under certain conditions for flow parameters, the vortex pair can reverse its motion within a bounded region.
C. M. Urry, E. Yu. Bannikova, E. Yu. Bannikova, G. M. Reznik, G. M. Reznik, H. Lamb, K. Yu. Bliokh, L. D. Landau, R. Antonucci, R. R. J. Antonucci, S. V. Alekseenko, V. M. Kontorovich, V. V. Meleshko, W. Jaffe   +13 more
core   +1 more source

SKOOTS: Skeleton‐Oriented Object Segmentation for Mitochondria in High‐Resolution Cochlear EM Datasets

Advanced Science, EarlyView.
Skeleton‐oriented object segmentation (SKOOTS) introduces a new strategy for 3D mitochondrial instance segmentation by predicting explicit skeletons rather than relying on boundary cues. This approach enables robust analysis of densely packed organelles in large FIB‐SEM datasets.
Christopher J. Buswinka, Richard T. Osgood, Hidetomi Nitta, Artur A. Indzhykulian   +3 more
wiley   +1 more source

THE LOGARITHMIC SPIRAL AND ITS SPHERICAL COUNTERPART

Journal of Industrial Design and Engineering Graphics, 2019
Logarithmic spirals are isogonal trajectories of pencils of lines. From a series of geometric consequences, we pick out a few which are relevant for kinematics: When a logarithmic spiral rolls on a line, its asymptotic point traces a straight line. Hence,
Hellmuth STACHEL, Giorgio FIGLIOLINI, Jorge ANGELES   +2 more
doaj  

An improved Harris hawks optimizer with enhanced logarithmic spiral and dynamic factor and its application for predicting molten iron temperature in the blast furnace

Engineering Reports
In response to the problem of poor search performance and difficulty in escaping from the local optimum in the Harris hawks optimizer, an improved Harris hawks optimizer with enhanced logarithmic spiral and dynamic factor (IHHO‐ELSDF) is proposed in this
Zhendong Liu, Yiming Fang, Le Liu, Shuidong Ma   +3 more
doaj   +1 more source

Spiral Galaxies Rotation Curves with a Logarithmic Corrected Newtonian Gravitational Potential

, 2007
We analyze the rotation curves of 10 spiral galaxies with a newtonian potential corrected with an extra logarithmic term, using a disc modelization for the spiral galaxies. There is a new constant associated with the extra term in the potential.
A. Kashlinsky, B. Famaey, B. Zwiebach, C. Brans, D. Bailin, F.C. Bosch van den, G. Bertone, G.W. Angus, G.W. Angus, H.H. Soleng, I.L. Shapiro, J. Bekenstein, J. Binney, J. C. Fabris, J. Pereira Campos, J.E. Lidsey, J.Ph. Bruneton, K.C. Freeman, L. Bergström, L. Randall, M. Milgrom, M.J. Duff, P. Letelier, P. Salucci, R. Colistete Jr, R. Colistete Jr, S. Capozziello, S. Capozziello, S. Weinberg   +28 more
core   +1 more source

Icariin Enhances the Enzymatic Activity of N‐acetylgalactosaminidase to Augment Akkermansia Abundance in Gut Microbiota for Improved PD‐1 Blockade Efficacy in Tumor Suppression

Advanced Science, EarlyView.
Icariin promoted the growth of Akk by enhancing the activity of N‐acetylgalactosaminidase (Amuc_0920), which enhanced mucin utilization and provided a favorable nutrient environment for bacterial growth. This icariin‐mediated enrichment of Akk further reshaped the tumor microenvironment and promoted CD8+ T cell infiltration, ultimately synergizing with
Shuangying Qiao, Liu Yang, Haibang Hao, Qiuxia Ding, Feng Ding, Zheng Chen, Jinfang Zhang, Yun He, Meng Li, Jun Xu, Chao Wang, Aiping Lu, Fangfei Li   +12 more
wiley   +1 more source