Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation
Molecular Oncology, EarlyView.How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim +11 more
wiley +1 more source
Costs, CO2 emissions and energy balances of applying Nordic slash recovery methods in British Columbia [PDF]
, 2011 This paper evaluates the costs, CO2 emissions and energy balances associated with three potential systems for recovering roadside slash in British Columbia, Canada, in which the biomass is transported as slash, hogfuel or bundles.
Sowlati, Taraneh +2 more
core +1 more source
Transcripts enriched in codons that trigger P‐site tRNA‐mediated mRNA decay possess stable mRNA
FEBS Open Bio, EarlyView.PTMD codons were first described by Mendel et al. as mediators of an mRNA decay pathway dependent on the human protein CNOT3, homologous to yeast Not5. Our findings confirm that PTMD codons destabilize transcripts; however, unlike in yeast, the human pathway specifically targets and slightly destabilizes primarily stable mRNAs.
Rodolfo Lopes Carneiro +1 more
wiley +1 more source
Loss of AMBRA1 activates MAPK and angiogenesis signaling pathways in melanoma cells
FEBS Open Bio, EarlyView.Loss of AMBRA1 in melanoma cells activates multiple oncogenic pathways associated with tumor progression. Transcriptomic and protein network analyses revealed that AMBRA1 depletion enhances MAPK/ERK signaling, angiogenesis, TGF‐β/EMT signaling, and Wnt/axon guidance pathways.
Milad Ibrahim +4 more
wiley +1 more source
Development of a method and equipment for processing wood biomass into flour [PDF]
BIO Web of ConferencesThe paper assesses the relevance of processing felling residues at logging sites into semi-finished wood products for further transportation and use at enterprises of the forestry and agro-industrial complex.
Zyryanov M.A., Ivantsova E.D.
doaj +1 more source
MagmaFlow: A desktop platform for artificial intelligence‐driven expression analysis
FEBS Open Bio, EarlyView.MagmaFlow is a free, no‐code platform for gene expression analysis. It generates interactive volcano plots, links genes to literature, pathways, and diseases, prioritizes candidates using millions of publications, identifies affected biological processes, builds network diagrams, and exports publication‐ready figures and reports for macOS and Windows ...
Carlos E. Buss +7 more
wiley +1 more source
Protein-bound veterinary drug residues in food [PDF]
, 1999 End of Project ReportBound residues of veterinary drugs have been recognised as an important aspect of food safety particularly (a) where such residues may persist for long periods after withdrawal of the drug treatment and (b) where the bound residues ...
Cadogan, Aodhmar +3 more
core +1 more source
Effects of repeated slash removal in thinned stands on soil chemistry and understorey vegetation
Silva Fennica, 2004 The increased interest in harvesting logging residues as a source of bio-energy has led to concerns about the potentially adverse long-term impact of the practice on site productivity. The aim of this study was to examine the effects on soil chemistry
Rosenberg, Olle, Jacobson, Staffan
doaj +1 more source
Influence of the Die Height on the Density of the Briquette Produced from Shredded Logging Residues. [PDF]
Materials (Basel), 2021 Nurek T, Gendek A, Dąbrowska M.
europepmc +1 more source
, 1992 Sponsored jointly by WHO and FAO with the support of the International Programme on Chemical SafetyWHO/PCS/92.52318 p.Presents detailed evaluations of the available toxicological and other safety data for sixteen pesticides that have the potential to ...
World Health Organization +3 more
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