Results 91 to 100 of about 823,716 (355)

Revealing the structure of land plant photosystem II: the journey from negative‐stain EM to cryo‐EM

open access: yesFEBS Letters, EarlyView.
Advances in cryo‐EM have revealed the detailed structure of Photosystem II, a key protein complex driving photosynthesis. This review traces the journey from early low‐resolution images to high‐resolution models, highlighting how these discoveries deepen our understanding of light harvesting and energy conversion in plants.
Roman Kouřil
wiley   +1 more source

Debate on long-acting β agonists for asthma:they think it's all over [PDF]

open access: yes, 2017
At last, we can apparently relax in the secure knowledge that long-acting β agonists (LABA) are safe to use in persistent asthma when given in combination with inhaled corticosteroid (ICS), on the basis of the US Food and Drug Administration-mandated ...
Bleecker   +11 more
core   +2 more sources

Mapping the evolution of mitochondrial complex I through structural variation

open access: yesFEBS Letters, EarlyView.
Respiratory complex I (CI) is crucial for bioenergetic metabolism in many prokaryotes and eukaryotes. It is composed of a conserved set of core subunits and additional accessory subunits that vary depending on the organism. Here, we categorize CI subunits from available structures to map the evolution of CI across eukaryotes. Respiratory complex I (CI)
Dong‐Woo Shin   +2 more
wiley   +1 more source

A US Retrospective Claims Analysis Comparing Healthcare Costs of Patients Transitioning from Immediate-Release Oxycodone to Two Different Formulations of Extended-Release Oxycodone: Xtampza ER or OxyContin

open access: yesClinicoEconomics and Outcomes Research, 2022
Oluwadara Olatoke,1 Vladimir Zah,1 Filip Stanicic,1 Djurdja Vukicevic,1 Platonas Yfantopoulos,1 Christy Thompson,2 Michael K DeGeorge,2 Steven Passik2 1HEOR Department, ZRx Outcomes Research, Mississauga, Ontario, Canada; 2Medical Department, Collegium ...
Olatoke O   +7 more
doaj  

Long-acting inhaled therapy (beta-agonists, anticholinergics and steroids) for COPD: a network meta-analysis. [PDF]

open access: yes, 2014
BACKGROUND: Pharmacological therapy for chronic obstructive pulmonary disease (COPD) is aimed at relieving symptoms, improving quality of life and preventing or treating exacerbations.Treatment tends to begin with one inhaler, and additional therapies ...
Aalbers   +511 more
core   +1 more source

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

open access: yesFEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi   +5 more
wiley   +1 more source

Long-term survival outcomes associated with inhalation therapy in chronic obstructive pulmonary disease: a 5-year multicenter prospective cohort study

open access: yesEuropean Journal of Medical Research
Background Chronic obstructive pulmonary disease (COPD) represents a significant global health challenge, characterized by high mortality rates. While inhalation therapies, specifically long-acting bronchodilators (LABD) and inhaled corticosteroids (ICS),
Genta Akiyama   +21 more
doaj   +1 more source

Patient-reported tolerability and acceptability of cabotegravir + rilpivirine long-acting injections for the treatment of HIV-1 infection: 96-week results from the randomized LATTE-2 study

open access: yesHIV Research & Clinical Practice, 2019
Background: Long-acting (LA) injectable antiretroviral therapy (ART) is a novel modality currently under development as an alternative to daily oral ART. Objective: The LATTE-2 study (ClinicalTrials.gov identifier NCT02120352) showed that cabotegravir LA 
Miranda Murray   +11 more
doaj   +1 more source

A Potential Long-Acting LDL-Cholesterol–Lowering PCSK9 Monoclonal Antibody

open access: gold, 2021
Yimin Cui   +9 more
openalex   +1 more source

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