Results 101 to 110 of about 7,499,902 (307)

Long-term survival outcomes associated with inhalation therapy in chronic obstructive pulmonary disease: a 5-year multicenter prospective cohort study

European Journal of Medical Research
Background Chronic obstructive pulmonary disease (COPD) represents a significant global health challenge, characterized by high mortality rates. While inhalation therapies, specifically long-acting bronchodilators (LABD) and inhaled corticosteroids (ICS),
Genta Akiyama, Hiroaki Ogata, Kazuya Tsubouchi, Tomotsugu Takano, Katsuyuki Ichiki, Ryo Torii, Shohei Takata, Noriaki Nakagaki, Makoto Yoshida, Yasuhiko Kitasato, Kazunori Tobino, Eiji Harada, Hiroshi Wataya, Hiroshi Ishii, Takashige Maeyama, Masayuki Kawasaki, Masaki Fujita, Kazuhiro Yatera, Yoshiaki Zaizen, Fumiaki Kiyomi, Yoichi Nakanishi, Isamu Okamoto   +21 more
doaj   +1 more source

Patient-reported tolerability and acceptability of cabotegravir + rilpivirine long-acting injections for the treatment of HIV-1 infection: 96-week results from the randomized LATTE-2 study

HIV Research & Clinical Practice, 2019
Background: Long-acting (LA) injectable antiretroviral therapy (ART) is a novel modality currently under development as an alternative to daily oral ART. Objective: The LATTE-2 study (ClinicalTrials.gov identifier NCT02120352) showed that cabotegravir LA 
Miranda Murray, Federico Pulido, Anthony Mills, Moti Ramgopal, Roger LeBlanc, Hans Jaeger, Viviam Canon, David Dorey, Sandy Griffith, Joseph Mrus, William Spreen, David Margolis   +11 more
doaj   +1 more source

Long-Acting Injectable Naltrexone for the Management of Patients with Opioid Dependence

, 2011
Opioid dependence is a condition with serious clinical ramifications. Treatment has focused on detoxification, agonist therapy with methadone or buprenorphine, or remission maintenance with the opioid antagonist, naltrexone.
Kimberly L. Kjome, F. Gerard Moeller
core   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

FEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee, Junho Jeong, Chae Yeong Lee, Hyunjoon Cho, Man Hwan Oh, Je Chul Lee, Jee‐Young Lee, Yangmee Kim   +7 more
wiley   +1 more source

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas F. Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

Sustained Release Drug Delivery Applications of Polyurethanes

Pharmaceutics, 2018
Since their introduction over 50 years ago, polyurethanes have been applied to nearly every industry. This review describes applications of polyurethanes to the development of modified release drug delivery.
Michael B. Lowinger, Stephanie E. Barrett, Feng Zhang, Robert O. Williams   +3 more
doaj   +1 more source

Patient perspectives on use of long-acting antipsychotics in bipolar disorder: focus on risperidone injection

, 2010
L Samalin, T Charpeaud, O Lorabi, PM LlorcaCentre Hospitalier Universitaire, Clermont-Ferrand, FranceAbstract: In the last few years, oral second-generation antipsychotics have demonstrated mood-stabilizing properties and are now widely used in the ...
T Charpeaud, L Samalin, et al, O Lorabi
core  

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source