Results 181 to 190 of about 823,716 (355)

Tumor mutational burden as a determinant of metastatic dissemination patterns

Molecular Oncology, EarlyView.
This study performed a comprehensive analysis of genomic data to elucidate whether metastasis in certain organs share genetic characteristics regardless of cancer type. No robust mutational patterns were identified across different metastatic locations and cancer types.
Eduardo Candeal, Andrea Moreno‐Manuel, Miguel Salvadó‐Pertierra, Cristina Santos‐Vivas, Rebeca Sanz‐Pamplona   +4 more
wiley   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Supplementary Table S1 from A Very Long-acting Exatecan and Its Synergism with DNA Damage Response Inhibitors

, 2023
Shaun D. Fontaine, Christopher W. Carreras, Ralph R. Reid, Gary W. Ashley, Daniel V. Santi   +4 more
openalex   +2 more sources

Long acting injectable antipsychotics – Where are we?

Telangana Journal of Psychiatry, 2015
Phani Prasant Mulakaluri
doaj   +1 more source

N-[(2-Sulfo)-9-fluorenylmethoxycarbonyl]₃-gentamicin C₁ Is a Long-Acting Prodrug Derivative

, 2002
Yoram Shechter, Haim Tsubery, Mati Fridkin   +2 more
openalex   +1 more source

A Rapid-onset, Long-acting Regional Anesthetic Technique [PDF]

, 1974
NELSON L. CUNNINGHAM, Joel A. Kaplan
openalex   +1 more source

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source

Preclinical Investigations of a Novel PEGylated Long-Acting Human Growth Hormone

Drug Design, Development and Therapy
Jun Wang,1,2 He Wang,1,2 Rong Wang,1,2 Yu Zhuang,1,2 Chenyang Jiang,1,2 Baixue Zhao,1,2 Zhen Xu,1,2 Bruce Yong Ma1,2 1Zonhon Biopharma Institute, Inc., Changzhou, Jiangsu, People’s Republic of China; 2Jiangsu Engineering Research Center for Precision ...
Wang J, Wang H, Wang R, Zhuang Y, Jiang C, Zhao B, Xu Z, Ma BY   +7 more
doaj  

A mixed-method study to inform the development of long-acting injectable TB treatments. [PDF]

IJTLD Open
Bayot AJF, Gler MT, Tolley EE, Lorenzetti L, Namey E, Dinh N, Martinez A, Audibert C, Foraida S, Osborn J, Holtzman D, Vinnard C, Talbot EA, Wells C.   +13 more
europepmc   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source