Results 161 to 170 of about 823,716 (355)

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

Effects of a single long-acting muscarinic antagonist agent and a long-acting muscarinic antagonist/long-acting β2-adrenoceptor agonist combination on lung function and symptoms in untreated COPD patients in Japan

, 2018
Hideyasu Yamada, Norihito Hida, Nobuyuki Hizawa   +2 more
openalex   +2 more sources

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Long-Acting Coronary Vasodilator Drugs:Metamine, Paveril, Nitroglyn and Peritrate [PDF]

, 1955
Henry I. Russek, Burton L. Zohman, ALICE E. DRUMM, William Weingarten, Virgil J. Dorset   +4 more
openalex   +1 more source

Infrared laser sampling of low volumes combined with shotgun lipidomics reveals lipid markers in palatine tonsil carcinoma

Molecular Oncology, EarlyView.
Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff, Manuela Moritz, Dennis Eggert, Anna Worthmann, Joerg Heeren, Henrike Zech, Till S. Clauditz, Waldemar Wilczak, Hartmut Schlüter, Christian S. Betz, Arne Böttcher, Jan Hahn   +11 more
wiley   +1 more source

Role of paliperidone palmitate 3-monthly in the management of schizophrenia: insights from clinical practice

Neuropsychiatric Disease and Treatment, 2019
Alicia Lopez, Jose Rey Department of Pharmacy Practice, Nova Southeastern University, Fort Lauderdale, FL, USA Abstract: Schizophrenia is a complex, chronic psychiatric disorder associated with reduced quality of life and shortened life span.
Lopez A, Rey J
doaj  

Effectiveness of long-acting reversible contraception [PDF]

, 2012
Allsworth, Jenifer E, Buckel, Christina, Madden, Tessa, Peipert, Jeffrey F, Secura, Gina M, Winner, Brooke, Zhao, Quihong   +6 more
core   +2 more sources

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

Level of Satisfaction Among Patients Using Insulin Administered by Pen vs Vial/Syringe. An Observational Prospective Study

Patient Preference and Adherence
Luis Fernando Valladales-Restrepo,1– 3 Ana Camila Delgado-Araujo,1 María Camila Oyuela-Gutiérrez,3 Harrison David Ospina-Arzuaga,1 Jorge Enrique Machado-Alba1 1Grupo de Investigación en Farmacoepidemiología y Farmacovigilancia, Universidad Tecnológica de
Valladales-Restrepo LF, Delgado-Araujo AC, Oyuela-Gutiérrez MC, Ospina-Arzuaga HD, Machado-Alba JE   +4 more
doaj  

Long-Term Effects of Depot Long-Acting Somatostatin Analog Octreotide on Hormone Levels and Tumor Mass in Acromegaly¹ [PDF]

, 2001
Annamaria Colao, Diego Ferone, Paolo Marzullo, Paolo Cappabianca, S. Cirillo, Viktor Boerlin, Ioana Lancranjan, Gaetano Lombardi   +7 more
openalex   +1 more source