Results 161 to 170 of about 7,499,902 (307)

Efficacy and safety of risperidone long-acting injection in elderly people with schizophrenia

open access: yes, 2009
Dhiren Singh1,2, Daniel W O’Connor11Department of Psychological Medicine, Monash University, Melbourne, Australia; 2Peninsula Mental Health Service, Melbourne, AustraliaAbstract: Antipsychotic medication is the mainstay of treatment in elderly
Daniel W O’Connor   +1 more
core  

Smaller is better: nanobodies meet NMR

open access: yesFEBS Letters, EarlyView.
Nanobodies are single‐domain antigen‐binding fragments derived from camelid heavy chain antibodies. Their small size, high stability, and exceptional specificity make nanobodies uniquely useful probes for NMR studies of protein dynamics, transient conformational states, and protein–protein interactions.
Oleg Y. Dmitriev
wiley   +1 more source

Long acting injectable antipsychotics – Where are we?

open access: yesTelangana Journal of Psychiatry, 2015
Phani Prasant Mulakaluri
doaj   +1 more source

Differential pharmacology and clinical utility of long-acting bronchodilators in COPD – focus on olodaterol

open access: yes, 2015
Maria Gabriella Matera,1 Josuel Ora,2 Mario Cazzola2,3 1Department of Experimental Medicine, Unit of Pharmacology, Second University of Naples, Naples, 2Division of Respiratory Medicine, University Hospital Tor Vergata, 3Department of Systems Medicine ...
Matera MG, Cazzola M, Ora J
core  

Membrane composition and thermodynamic identity as boundaries of life for synthetic cell research

open access: yesFEBS Letters, EarlyView.
What makes a cell a cell? The boundary of a living cell is not just a wall. Read as a Markov blanket, the membrane separates internal from external states, generating identity and non‐equilibrium order. Can this identity be rebuilt from scratch in a synthetic cell?
Caterina Presutti, Bert Poolman
wiley   +1 more source

Preclinical Investigations of a Novel PEGylated Long-Acting Human Growth Hormone

open access: yesDrug Design, Development and Therapy
Jun Wang,1,2 He Wang,1,2 Rong Wang,1,2 Yu Zhuang,1,2 Chenyang Jiang,1,2 Baixue Zhao,1,2 Zhen Xu,1,2 Bruce Yong Ma1,2 1Zonhon Biopharma Institute, Inc., Changzhou, Jiangsu, People’s Republic of China; 2Jiangsu Engineering Research Center for Precision ...
Wang J   +7 more
doaj  

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

open access: yesMolecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce   +11 more
wiley   +1 more source

Relationship of inhaled long-acting bronchodilators with cardiovascular outcomes among patients with stable COPD: a meta-analysis and systematic review of 43 randomized trials

open access: yes, 2019
Chenxi Li,1 Wenke Cheng,2 Jin Guo,1 Wei Guan11Department of Respiratory, Affiliated Hospital of Qinghai University, Xining, People’s Republic of China; 2Department of Cardiology, Affiliated Hospital of Qinghai University, Xining, People’s ...
Guo J, Guan W, Cheng WK, Li CX
core  

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

open access: yesMolecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

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