Results 141 to 150 of about 823,716 (355)

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Utilization Pattern of Long-Acting and Permanent Family Planning Methods and Associated Factors: A Community-Based Cross-Sectional Study in Ethiopia

Open Access Journal of Contraception, 2020
Chilot Abiyu Demeke,1,* Asmamaw Emagn Kasahun,1,* Wudneh Simegn Belay,1 Abay Nega Chekol,2 Rahel Alemu Getaneh,2 Dawit Kumilachew Yimenu1 1Department of Pharmaceutics and Social Pharmacy, School of Pharmacy, College of Medicine and Health Sciences ...
Demeke CA, Kasahun AE, Belay WS, Chekol AN, Getaneh RA, Yimenu DK   +5 more
doaj  

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

FEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

Comparison of opioid prescribing by dentists in the United States and England [PDF]

, 2019
Importance: The United States consumes most of the opioids worldwide despite representing a small portion of the world\u27s population. Dentists are one of the most frequent US prescribers of opioids despite data suggesting that nonopioid analgesics are ...
Calip, Gregory S, Durkin, Michael J, Gellad, Walid F, Kim, Hajwa, Lockhart, Peter B, Rowan, Susan A, Suda, Katie J, Thornhill, Martin H   +7 more
core   +1 more source

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source

Increasing CD4/CD8 ratio confirmed after two years of long-acting cabotegravir and rilpivirine in the SCohoLART study

Frontiers in Virology
BackgroundLong-acting (LA) cabotegravir plus rilpivirine (CAB/RPV) is an established maintenance option for virologically suppressed people with HIV (PWH), but long-term real-world data on immune balance and cardio-metabolic and renal markers remain ...
Gabriele Loi, Nicolò Capra, Riccardo Lolatto, Marcella Negri, Gaia Catalano, Flavia Passini, Nicolò Moschetta, Claudia Benelli, Silvia Nozza, Silvia Nozza, Antonella Castagna, Antonella Castagna, Camilla Muccini   +12 more
doaj   +1 more source

671: A randomized controlled trial comparing two post cesarean analgesia protocols: long acting spinal morphine versus fixed time interval oral analgesia [PDF]

, 2016
Enav Yefet, Salih Nassar, Yulia Carmeli, Manal Massalha, Michael Rudin, Jamal Hasanein, Noah Zafran, Zohar Nachum   +7 more
openalex   +1 more source