Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source
Patient and provider preferences for long-acting TB preventive therapy
IJTLD OpenBACKGROUND: Tuberculosis preventive therapy (TPT) is critical for TB elimination but is underutilised. Long-acting (LA) TPT can potentially improve linkage to care, treatment adherence and outcomes.
M. Vermeulen +17 more
doaj +1 more source
Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source
Gastric endocrine tumors type I: treatment with long-acting somatostatin analogs [PDF]
, 2008 Davide Campana +7 more
openalex +1 more source
PREVALENCE OF ASTHMA CONTROL AND THE ASSOCIATED DISEASE BURDEN IN US PATIENTS WITH ASTHMA TREATED WITH A FIXED-DOSE COMBINATION OF INHALED CORTICOSTEROID AND LONG-ACTING BETA2-AGONIST [PDF]
, 2020 Shiyuan Zhang +9 more
openalex +1 more source
Potential therapeutic targeting of BKCa channels in glioblastoma treatment
Molecular Oncology, EarlyView.This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
wiley +1 more source
Activity of a long-acting injectable bedaquiline formulation in a paucibacillary mouse model of latent tuberculosis infection [PDF]
, 2019 Amit Kaushik +7 more
openalex +1 more source
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
Advances in Long-Acting Injectable Drug Delivery: Formulation Science, Emerging Technologies, and Future Perspectives [PDF]
P THEYANESHWARAN +3 more
openalex +1 more source