Results 231 to 240 of about 823,716 (355)

Preference for Service Delivery for Long-Acting Pre-exposure Prophylaxis for HIV Infection Among Pregnant and Breastfeeding Women in South Africa and Botswana [PDF]

Lindsey de Vos, Aamirah Mussa, Elzette Rousseau, M. Strauss, Gavin George, Prisca Vundhla, Avuyonke Gebengu, Maipelo Tsuaneng, Lefhela Tamuthiba, Aratwa Tumagole, Neo Moshashane, Chelsea Morroni, Remco P. H. Peters, Chibuzor M. Babalola, Jeffrey D. Klausner, Dvora Joseph Davey   +15 more
openalex   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Stearic acid-modified PSMA-targeting peptide-drug conjugate for long-acting prostate cancer therapy. [PDF]

Chem Sci
Qiu Z, Zheng X, Pan S, Zhong Y, Chen X, Wen X, Chen X, Li S, Cheng H, Chen X.   +9 more
europepmc   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Evening administration of long-acting muscarinic antagonists in COPD - a randomized controlled trial. [PDF]

BMC Pulm Med
Sivapalan P, Rømer V, Jordan A, Johansen ND, Pareek M, Modin D, Mathioudakis AG, Vestbo J, Vognsen AK, Eklöf J, Hurst JR, Klausen TW, Biering-Sørensen T, Jensen JS.   +13 more
europepmc   +1 more source

Aripiprazole Long-acting Injectable Two-injection Start to Manage Supersensitivity Psychosis: A Case Report

Hazal Yavuzlar Cıvan
openalex   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Long-acting β₂-agonists (LABA) in chronic obstructive pulmonary disease: efficacy and safety

, 2008
Andrea Rossi
openalex   +2 more sources

NKCC1: A key regulator of glioblastoma progression

Molecular Oncology, EarlyView.
Glioblastoma (GBM) progression is driven by disrupted chloride cotransporter homeostasis. NKCC1 is highly expressed in stem‐like, astrocytic, and progenitor cells, correlating with earlier recurrence, while overall survival remains unaffected. NKCC1 serves as a prognostic marker and potential therapeutic target, linking chloride transporter imbalance ...
Anja Thomsen, Diana Freitag, Madlen Haase, Christian Senft, Falko Schwarz, Silke Keiner   +5 more
wiley   +1 more source

Long-acting interleukin-7 improves the efficacy of oncolytic viral therapy in glioblastoma. [PDF]

Nat Commun
Li YD, Giles DA, Huang Y, Kesarwani A, Hu T, Page L, de Andrade Costa A, Luo J, Wolfarth A, Choi D, Dang MT, Kim AH, DiPersio JF, Curiel DT, Diamond MS, Chheda MG.   +15 more
europepmc   +1 more source