Results 281 to 290 of about 823,716 (355)

An ultra-long-acting dimeric bictegravir prodrug defined by a short pharmacokinetic tail. [PDF]

Nat Commun
Nayan MU, Sillman B, Das S, Hanson BW, Sultana A, Le NTH, Deodhar S, Gowda B, Dash PK, Agrawal S, Dash AK, Cohen SM, Zhang C, Gendelman HE, Edagwa B.   +14 more
europepmc   +1 more source

HIV‐1 establishes immediate latency in T cells expressing the viral Nef protein

FEBS Open Bio, EarlyView.
Nef is a viral protein often omitted from HIV‐1 reporter viruses. Consequently, its role in viral latency is unclear. We developed three novel dual reporter HIV‐1 derivatives that express Nef and allow for detection of latent and productive infection. Using these reporters, we show that Nef does not affect the establishment of immediate viral latency ...
Cindy Lam, Ivan Sadowski
wiley   +1 more source

The Promises and Prospects of Long-Acting Therapeutics for Treatment and Prevention of Infectious Diseases. [PDF]

Annu Rev Pharmacol Toxicol
Olagunju A, Perazzolo S, Stephen ZR, Ryan M, Xu X, Venkatasubramanian P, Atoyebi S, Fratte RD, Owen A, Flexner C, Ho RJY.   +10 more
europepmc   +1 more source

Preferences and feasibility of long‐acting technologies for treatment of hepatitis C virus in low‐ and middle‐income countries: A survey of providers and policymakers

Neil Gupta, Susan Swindells, Kimberly K. Scarsi, Renae Furl, David L. Thomas, Ethel D. Weld, Joelle Dountio Ofimboudem, Hailemichael Desalegn, Saeed Hamid, Alethse De la Torre Rosas, Angélica Espinosa Miranda, Andrew Owen, Steve P. Rannard, Lindsey Hiebert, Katherine Sun, John W. Ward   +15 more
openalex   +2 more sources

BMI‐1 modulation and trafficking during M phase in diffuse intrinsic pontine glioma

FEBS Open Bio, EarlyView.
The schematic illustrates BMI‐1 phosphorylation during M phase, which triggers its translocation from the nucleus to the cytoplasm. In cycling cells, BMI‐1 functions within the PRC1 complex to mediate H2A K119 monoubiquitination. Following PTC596‐induced M phase arrest, phosphorylated BMI‐1 dissociates from PRC1 and is exported to the cytoplasm via its
Banlanjo Umaru, Deepak Kumar Mishra, Shiva Senthil Kumar, Hao‐Han Pang, Brendan Devine, Komal Khan, Rachid Drissi   +6 more
wiley   +1 more source

Brief Report: Long-Acting Injectable PrEP Can Substantially Reduce HIV Incidence in Los Angeles County: A Simulation Study. [PDF]

J Acquir Immune Defic Syndr
Khanna A, Lee F, Schrode K, Sheeler D, Hotton A, Schneider J, Fujimoto K, Chirumamilla S, Kwa Sey E, Harawa NT.   +9 more
europepmc   +1 more source

KBG Syndrome: A Case Report and Longitudinal Assessment of Long-Acting Recombinant Human Growth Hormone Therapy. [PDF]

Clin Case Rep
Nan H, Zhang P, Qian J.
europepmc   +1 more source

Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of the Novel Long-Acting FGF21 Analog Zalfermin. [PDF]

Clin Transl Sci
Dahl K, Friedrichsen MH, Ribel-Madsen R, Hansen JS, Clausen JO, Axelsen M, Palle MS, Lippert SL, Björkdahl O, Toubro S, Key C, Andersen B.   +11 more
europepmc   +1 more source

The effect of switching antipsychotics to aripiprazole versus paliperidone on weight/cardiometabolic parameters: 18-month follow-up findings from the European Long-acting Antipsychotics in Schizophrenia Trial (EULAST)

Nini de Boer, Zara Vučko, Derek IJsbrand Koster, Marte van der Horst, Michael Davidson, Wiepke Cahn, Jurjen J. Luykx   +6 more
openalex   +1 more source