Results 221 to 230 of about 126,067 (267)

Long-acting anticholinergics in the treatment of severe asthma with irreversible airway obstruction

European Respiratory Journal, 2014
Introduction. Patients with severe asthma tend to have impaired lung function and irreversible airway obstruction (IAO), which can lead to lower sensitivity of these patients to standard therapy. It is assumed that long-acting anticholinergic drug (tiotropium bromide) can be useful in severe asthma as additional
Olga Kharevich, Irina Lapteva, Elena Lapteva, Galina Novskaya, Irina Lantukhova, Irina Dovnar, Olga Burak   +6 more
openaire   +2 more sources

Ba 679 BR, A novel long-acting anticholinergic bronchodilator

Life Sciences, 1993
The use of anticholinergics in antiobstructive therapy is well established in pulmonary medicine. We sought to improve the duration of action of inhaled antimuscarinics. A newly developed compound, Ba 679 BR (abbreviated Ba 679) proved to be a highly potent muscarinic antagonist in guinea pig tracheal rings.
B, Disse, R, Reichl, G, Speck, W, Traunecker, K L, Ludwig Rominger, R, Hammer   +5 more
openaire   +3 more sources

Irisin is associated with clinical outcomes and up-regulated by long-acting anticholinergics in COPD

Airway Cell Biology and Immunopathology, 2017
Irisin is a myokine suggested to regulate energy expenditure and exercise capacity. It is regulated by peroxisome proliferator-activated receptor-γ coactivator-1-α (PGC1-a) and is proteolytically cleaved from fibronectin-type-III domain-containing protein-5 (FNDC5).
Eleni Papakonstantinou, Michael Roth, Jyotshna Mandal, Qingzhu Sun, Luigi Costa, Lucas Boeck, Andreas Scherr, Janko Rakic, Renaud Louis, Branislava Milenkovic, Wim Boersma, Konstantinos Kostikas, Francesco Blasi, Joachim Aerts, Gernot Rohde, Alicia Lacoma, Antoni Torres, Tobias Welte, Daiana Stolz, Michael Tamm   +19 more
openaire   +2 more sources

Preclinical Evaluation of Long Acting Anticholinergics (LAAC): Comparison of Tiotropium and Investigational Drugs.

C49. COPD: PHARMACOLOGICAL TREATMENT LAMA, 2009
P Casarosa, T Bouyssou, F Gantner, MP Pieper   +3 more
openaire   +2 more sources

Cardiovascular Safety of Inhaled Long-Acting Bronchodilators in Individuals With Chronic Obstructive Pulmonary Disease

JAMA Internal Medicine, 2013
Andrea S Gershon, Ruth Croxford, Andrew Calzavara   +2 more
exaly   +2 more sources

Long-Acting Bronchodilator Therapy for the Treatment of Chronic Obstructive Pulmonary Disease

Annals of Pharmacotherapy, 2008
Andrea M Chen, S. Bollmeier, P. Finnegan
exaly   +2 more sources

Impact of long-acting injectable aripiprazole on the concomitant medication and antipsychotic polypharmacy: a retrospective, observational study of 127 patients with psychosis

International Clinical Psychopharmacology, 2023
Antipsychotic polypharmacy (APP) has become prevalent over the years, but several concerns have been raised over APP. Accumulating evidence suggests that aripiprazole long-acting injectable (LAI) may reduce the rate of APP, but the association remains ...
Junhee Lee, Sanghoon Oh, Sun-Young Moon, Silvia Kyungjin Loh, Minah Kim, Tae Young Lee, J. Kwon   +6 more
semanticscholar   +1 more source

The Role of Tiotropium Bromide, a Long-Acting Anticholinergic Bronchodilator, in the Management of COPD

Treatments in Respiratory Medicine, 2005
Bronchodilator therapy forms the mainstay of treatment for symptomatic patients with COPD. Long-acting bronchodilators, which maintain sustained airway patency over a 24-hour period, represent an advance in therapy. Tiotropium bromide is a new long-acting inhaled anticholinergic agent with superior pharmacodynamic properties compared with the short ...
Farzad, Saberi, Denis E, O'Donnell
openaire   +2 more sources

Tiotropium: An Inhaled, Long‐Acting Anticholinergic Drug for Chronic Obstructive Pulmonary Disease

Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy, 2003
Inhaled anticholinergic drugs are considered one of the principal bronchodilator treatments for chronic obstructive pulmonary disease (COPD). Ipratropium bromide is an anticholinergic drug frequently administered for the treatment of COPD. Unfortunately, ipratropium has a short duration of action, requiring administration every 6 hours; this regimen ...
Chad A, Panning, Mike, DeBisschop
openaire   +2 more sources

Comparison of the efficacy and safety of long-acting anticholinergic and a combination of inhaled steroids and long-acting beta-2 agonist in moderate chronic obstructive pulmonary disease

European Respiratory Journal, 2013
Long-acting anticholinergics and inhaled steroid-long acting beta-agonist combinations are frequently prescribed in moderate COPD.We aimed to compare the efficacy and safety of these drugs in patients with moderate COPD.A total of 44 patients who ...
Pinar Sarac, A. Sayıner
semanticscholar   +1 more source