Results 61 to 70 of about 126,067 (267)

The in vivo efficacy and side effect pharmacology of GS-5759, a novel bifunctional phosphodiesterase 4 inhibitor and long-acting β2-adrenoceptor agonist in preclinical animal species

Pharmacology Research & Perspectives, 2014
Bronchodilators are a central therapy for symptom relief in respiratory diseases such as chronic obstructive pulmonary disease (COPD) and asthma, with inhaled β2‐adrenoceptor agonists and anticholinergics being the primary treatments available.
M. Salmon, S. Tannheimer, Terry T. Gentzler, Z. Cui, Eric A. Sorensen, Kim Hartsough, Musong Kim, L. Purvis, E. Barrett, J. McDonald, K. Rudolph, M. Doyle‐Eisele, P. Kuehl, C. Royer, W. Baker, G. Phillips, C. Wright   +16 more
semanticscholar   +1 more source

COST-MINIMIZATION OF VILANTEROL / UMECLIDINIUM VERSUS OLODATEROL / TIOTROPIUM IN THE BASIC THERAPY OF SEVERE AND VERY SEVERE COPD

Фармакоэкономика, 2017
The recently introduced novel drug combinations for the treatment of COPD are based on long-acting beta-agonists (vilantererol / umeclidinum bromide) and long-acting anticholinergics (olodaterol / tiotropium bromide).
E. G. Kosolapov, F. S. Kochenkov, N. L. Pogudina, D. V. Blinov, N. L. Bondarenko, A. V. Karaulov   +5 more
doaj   +1 more source

Long-acting anticholinergic agents in patients with uncontrolled asthma: a systematic review and meta-analysis

The International Journal of Tuberculosis and Lung Disease, 2014
A novel effective treatment is necessary for severe asthma.To review clinical trials examining the role of tiotropium in patients with poorly controlled asthma despite inhaled corticosteroid use with or without long-acting β₂-agonists.A computerised search of electronic databases (Medline, EMBASE and Cochrane Central Register) was performed. Randomised
S W, Lee, H J, Kim, K H, Yoo, Y B, Park, J-Y, Park, J Y, Jung, J-Y, Moon, M K, Byun, S W, Kim, Y H, Kim   +9 more
openaire   +3 more sources

Choice of therapy for patients who do not achieve control over bronchial asthma on basic therapy with medium doses of inhaled glucocorticosteroids/long-acting β2-agonists. Resolution of the Expert Council

PULMONOLOGIYA
Recently, new drugs for the treatment of bronchial asthma (BA) have been registered in the Russian Federation: fixed triple combinations, which include inhaled corticosteroids (ICS), long-acting β2-agonists (LABA) and anticholinergics, high-dose ...
S. Avdeev, Z. Aisanov, V. V. Arkhipov, A. Belevskiy, N. Ilyina, O. Kurbacheva, N. Nenasheva   +6 more
semanticscholar   +1 more source

Medication Knowledge of Patients with Parkinson's Disease: Strengths and Gaps

Movement Disorders Clinical Practice, EarlyView.
Abstract Background Effective drug treatment of motor and non‐motor symptoms in Parkinson's disease (PD) often requires the administration of several anti‐Parkinson drugs in complex treatment regimens. The successful autonomous application of drugs places high demands on therapy adherence, which in turn relies on sufficient medication knowledge ...
Stephan Greten, Sarana Ulaganathan, Johannes Heck, Lan Ye, Matthias Höllerhage, Christoph Schrader, Corinna Ziemann, Olaf Krause, Florian Wegner, Martin Klietz   +9 more
wiley   +1 more source

The Spectrum of Abnormal Tongue Movements: Review of Phenomenology, Etiology, and Differential Diagnosis

Movement Disorders Clinical Practice, EarlyView.
ABSTRACT Background Classifying abnormal tongue movements is challenging due to their varied presentations and limited visibility compared to other body parts. Accurate identification of the phenomenology guides physical examination and can point to specific diagnoses.
Nathaniel Bendahan, Seyed‐Mohammad Fereshtehnejad, Christos Ganos, Emily Swinkin, Anthony E. Lang   +4 more
wiley   +1 more source

New pharmacological options in the chronic obstructive pulmonary disease

Revista Electrónica Dr. Zoilo E. Marinello Vidaurreta, 2016
Chronic obstructive pulmonary disease is a disseminated process with important clinical and economic implications. A bibliographic review of scientific articles published in PubMed, Scielo and MEDLINE between 2010 and 2015 was carried out concerning the ...
Surama Martínez Chávez, Igber González de la Cruz, Alfredo Enrique Arredondo Bruce   +2 more
doaj  

Potentially inappropriate medications in relation to length of nursing home stay among older adults

BMC Geriatrics, 2022
Background To investigate the use of potentially inappropriate medications and their relation to the length of nursing home stay among older adults. Methods Questionnaire surveys using the Multi-Dimensional Dementia Assessment scale were sent out to all ...
Eva Sönnerstam, Maria Gustafsson, Hugo Lövheim   +2 more
doaj   +1 more source

β2 long-acting and anticholinergic drugs control TGF-β1-mediated neutrophilic inflammation in COPD

Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, 2012
AbstractWe quantified TGF-β1 and acetylcholine (ACh) concentrations in induced sputum supernatants (ISSs) from 18 healthy controls (HC), 22 healthy smokers (HS) and 21 COPDs. ISSs from HC, HS and COPD as well as rhTGF-β1 were also tested in neutrophil adhesion and in mAChR2, mAChR3 and ChAT expression experiments in human bronchial epithelial cells (16-
Mirella Profita a, Anna Bonanno a, Angela Marina Montalbano a, Giusy Daniela Albano a b, Loredana Riccobono a, Liboria Siena a, Maria Ferraro a, Paola Casarosa c, Michael Paul Pieper c, Mark Gjomarkaj   +9 more
openaire   +3 more sources

Exocrine Gland Dysfunction in Parkinson's Disease: Pathophysiology, Clinical Manifestations, and Therapeutic Perspectives—A Narrative Review

Movement Disorders Clinical Practice, EarlyView.
Abstract Background Non‐motor symptoms, especially autonomic dysfunction, are major contributors to disability and decreased quality of life in Parkinson's disease (PD). Despite being common and having a wide range of clinical facets, exocrine gland dysfunction is still not well recognized and managed.
Renato P. Munhoz, Marina Farah, Laura Silveira‐Moriyama   +2 more
wiley   +1 more source