Results 261 to 270 of about 296,746 (277)
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CRISPR-Cas9 Long-Read Sequencing for Mapping Transgenes in the Mouse Genome
The CRISPR Journal, 2023Microinjected transgenes, both large and small, are known to insert randomly into the mouse genome. Traditional methods of mapping a transgene are challenging, thus complicating breeding strategies and accurate interpretation of phenotypes, particularly when a transgene disrupts critical coding or noncoding sequences. As the vast majority of transgenic
W. Bart Bryant +9 more
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COmapper : high‐resolution mapping of meiotic crossovers by long‐read sequencing in Arabidopsis
New PhytologistMeiotic crossovers rearrange existing genetic variation between homologous chromosomes, profoundly affecting genomic diversity. Crossovers are typically constrained to one to three events per chromosome pair, and their distribution is shaped by chromatin
Dohwan Byun, Namil Son, Juhyun Kim
exaly +3 more sources
Acceleration of the long read mapping on a PC-FPGA architecture (abstract only)
Proceedings of the ACM/SIGDA international symposium on Field programmable gate arrays, 2013The genome sequence alignment, whereby ultra scale of sequence reads should be compared to an enormous long reference, has been one central challenge to the biologists for a long period. For recent years, new sequencing technology makes it possible to generate longer reads (sequences of genome fragments) which seem more valuable for the life science ...
Peng Chen 0004 +3 more
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No-mapping mapping of Oxford Nanopore long reads
2023Strzoda, Tomasz +4 more
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mapAlign: An Efficient Approach for Mapping and Aligning Long Reads to Reference Genomes
2020Long reads play an important role for the identification of structural variants, sequencing repetitive regions, phasing of alleles, etc. In this paper, we propose a new approach for mapping long reads to reference genomes. We also propose a new method to generate accurate alignments of the long reads and the corresponding segments of reference genome ...
Wen Yang 0019, Lusheng Wang 0001
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Long Read Mapping at Scale: Algorithms and Applications.
2019Capability to sequence DNA has been around for four decades now, providing ample time to explore its myriad applications and the concomitant development of bioinformatics methods to support them. Nevertheless, disruptive technological changes in sequencing often upend prevailing protocols and characteristics of what can be sequenced, necessitating a ...
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An Efficient Parallel Sketch-based Algorithm for Mapping Long Reads to Contigs
2023 IEEE International Parallel and Distributed Processing Symposium Workshops (IPDPSW), 2023Tazin Rahman +2 more
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A Fast Approximate Algorithm for Mapping Long Reads to Large Reference Databases
Journal of Computational Biology, 2018Chirag Jain +2 more
exaly