Results 31 to 40 of about 225,232 (252)
ARKS: chromosome-scale scaffolding of human genome drafts with linked read kmers
BMC Bioinformatics, 2018 Background The long-range sequencing information captured by linked reads, such as those available from 10× Genomics (10xG), helps resolve genome sequence repeats, and yields accurate and contiguous draft genome assemblies.
Lauren Coombe +6 more
doaj +1 more source
Storage of photonic time-bin qubits for up to 20 ms in a rare-earth doped crystal
npj Quantum Information, 2022 Long-duration quantum memories for photonic qubits are essential components for achieving long-distance quantum networks and repeaters. The mapping of optical states onto coherent spin-waves in rare earth ensembles is a particularly promising approach to
Antonio Ortu +3 more
doaj +1 more source
Disentangled Long-Read De Bruijn Graphs via Optical Maps [PDF]
, 2016 AbstractPacific Biosciences (PacBio), the main third generation sequencing technology can produce scalable, high-throughput, unprecedented sequencing results through long reads with uniform coverage. Although these long reads have been shown to increase the quality of draft genomes in repetitive regions, fundamental computational challenges remain in ...
Alipanahi, Bahar +4 more
openaire +4 more sources
PBHoney: identifying genomic variants via long-read discordance and interrupted mapping [PDF]
BMC Bioinformatics, 2014 As resequencing projects become more prevalent across a larger number of species, accurate variant identification will further elucidate the nature of genetic diversity and become increasingly relevant in genomic studies. However, the identification of larger genomic variants via DNA sequencing is limited by both the incomplete information provided by ...
English, Adam C +2 more
openaire +2 more sources
High-resolution transcriptome analysis with long-read RNA sequencing.
PLoS ONE, 2014 RNA sequencing (RNA-seq) enables characterization and quantification of individual transcriptomes as well as detection of patterns of allelic expression and alternative splicing.
Hyunghoon Cho +5 more
doaj +1 more source
A new hash function and its use in read mapping on genome [PDF]
AUT Journal of Mathematics and Computing, 2020 Mapping reads onto genomes is an indispensable step in sequencing data analysis. A widely used method to speed up mapping is to index a genome by a hash table, in which genomic positions of $k$-mers are stored in the table.
Farzaneh Salari +2 more
doaj +1 more source
Stranded Mapping from Long Reads v3 [PDF]
, 2018 This protocol demonstrates how to convert raw long reads produced using a strand-specific sequencing protocol (e.g. ONT's strand-switching protocol) into strand-specific mapped reads. The general ides is to use LAST to identify the adapter orientation relative to the genome, and then use that information to reorient called sequences to create a ...
openaire +1 more source
A long read mapping method for highly repetitive reference sequences [PDF]
, 2020 AbstractAbout 5-10% of the human genome remains inaccessible for functional analysis due to the presence of repetitive sequences such as segmental duplications and tandem repeat arrays. To enable high-quality resequencing of personal genomes, it is crucial to support end-to-end genome variant discovery using repeat-aware read mapping methods.
Chirag Jain +4 more
openaire +1 more source
Pediatric Blood &Cancer, EarlyView.ABSTRACT Neuroblastoma is the most common extracranial solid tumor in early childhood. Its clinical behavior is highly variable, ranging from spontaneous regression to fatal outcome despite intensive treatment. The International Society of Pediatric Oncology Europe Neuroblastoma Group (SIOPEN) Radiology and Nuclear Medicine Specialty Committees ...
Annemieke Littooij +11 more
wiley +1 more source
Wochenende — modular and flexible alignment-based shotgun metagenome analysis
BMC Genomics, 2022 Background Shotgun metagenome analysis provides a robust and verifiable method for comprehensive microbiome analysis of fungal, viral, archaeal and bacterial taxonomy, particularly with regard to visualization of read mapping location, normalization ...
Ilona Rosenboom +12 more
doaj +1 more source