Results 201 to 210 of about 4,235,672 (400)

Meisoindigo Acts as a Molecular Glue to Target PKMYT1 for Degradation in Chronic Myeloid Leukemia Therapy

Advanced Science, EarlyView.
Meisoindigo targets PKMYT1 for degradation by acting as a molecular glue that enhances PKMYT1‐TRIM25 interaction, leading to K48‐linked ubiquitination and subsequent proteasomal degradation, thereby exerting therapeutic effects in chronic myeloid leukemia.
Zhao‐Xin Zhang, Shu‐Ying Li, Fang‐Fei Li, Qin‐Yan Shi, Cheng‐Yong Tan, Xiao‐Jing Wang, Mi Li, Yun‐Bao Liu, Jing Jin, Yong Li, Shi‐Shan Yu   +10 more
wiley   +1 more source

HCN1 channels mediate mu opioid receptor long-term depression at insular cortex inputs to the dorsal striatum. [PDF]

J Physiol, 2022
Munoz B, Fritz BM, Yin F, Atwood BK.
europepmc   +1 more source

Long-Term Depression and Depotentiation in the Sensorimotor Cortex of the Freely Moving Rat [PDF]

, 2000
David J. Froc, C. Andrew Chapman, Christopher Trepel, Ronald J. Racine   +3 more
openalex   +1 more source

Therapeutic Delivery of circDYM by Perillyl Alcohol Nanoemulsion Alleviates LPS‐Induced Depressive‐Like Behaviors

Advanced Science, EarlyView.
PANEs are specifically designed to enhance the brain delivery efficiency of circDYM compared to commercialized lipid nanoparticles (LNPs). Intranasal administration of PANE‐circDYM effectively alleviated LPS‐induced depressive‐like behaviors by mitigating neuroinflammation and promoting neuroplasticity.
Feng Gao, Zhongkun Zhang, Minzi Ju, Liang Bian, Huijuan Wang, Sibo Zhao, Ningbo Cai, Yu Wang, Yanpeng Jia, Ling Shen, Yuan Zhang, Honghong Yao   +11 more
wiley   +1 more source

Long-term depression in neurons involves temporal and ultra-structural dynamics of phosphatidylinositol-4,5-bisphosphate relying on PIP5K, PTEN and PLC. [PDF]

Commun Biol, 2023
Hofbrucker-MacKenzie SA, Seemann E, Westermann M, Qualmann B, Kessels MM.   +4 more
europepmc   +1 more source

Roles of ATP and adenosine derivatives for frequency-dependent changes of synaptic connections, long-term potentiation(LTP) and long-term depression(LTD).

, 1990
Yoichiro Kuroda
openalex   +2 more sources

Long-Term Depression of the Cerebellar Climbing Fiber–Purkinje Neuron Synapse [PDF]

, 2000
Christian Hansel, David J. Linden
openalex   +1 more source

Glutamatergic synapses are structurally and biochemically complex because of multiple plasticity processes: long-term potentiation, long-term depression, short-term potentiation and scaling

Philosophical Transactions of the Royal Society B: Biological Sciences, 2017
J. Lisman
semanticscholar   +1 more source

Development of Carbon‐11 Labeled Pyrimidine Derivatives as Novel Positron Emission Tomography (PET) Agents Enabling Brain Sigma‐1 Receptor Imaging

Advanced Science, EarlyView.
Novel carbon‐11 labeled pyrimidine derivatives are developed as PET imaging probes for visualizing sigma‐1 receptors in the brain. [11C]CNY‐01 demonstrates superior brain uptake and binding specificity in both rodents and non‐human primates. The study reveals decreased sigma‐1 receptor expression in Alzheimer's disease, offering a promising tool for ...
Ping Bai, Ashley Gomm, Chi‐Hyeon Yoo, Prasenjit Mondal, Fleur Marie Lobo, Hui Meng, Yanting Zhou, Weiyao Xie, Hsiao‐Ying Wey, Rudolph E. Tanzi, Can Zhang, Changning Wang, Yu Lan   +12 more
wiley   +1 more source

Synaptic homeostasis transiently leverages Hebbian mechanisms for a multiphasic response to inactivity

Cell Reports
Summary: Homeostatic regulation of synapses is vital for nervous system function and key to understanding a range of neurological conditions. Synaptic homeostasis is proposed to operate over hours to counteract the destabilizing influence of long-term ...
Simón(e) D. Sun, Daniel Levenstein, Boxing Li, Nataniel Mandelberg, Nicolas Chenouard, Benjamin S. Suutari, Sandrine Sanchez, Guoling Tian, John Rinzel, György Buzsáki, Richard W. Tsien   +10 more
doaj