Results 201 to 210 of about 525,185 (258)
Advanced Science, EarlyView.A universal ROR1 antibody‐engineered lipid nanoparticle (LNP) is constructed by sequential drug encapsulation and antibody conjugation. The LNP not only enables enhanced chemotherapeutic efficiency by targeting drug delivery and precise localization of deep‐seated tumors through NIR‐II fluorescence imaging, but also remodels immunosuppressive TME ...
Yeneng Dai +12 more
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Advanced Science, EarlyView.The functionalized starch modifies the mitochondrial surface and encapsulates resveratrol into the cavity of helices, facilitating a novel mitochondrial transplantation platform (MLSR). Upon internalization in recipient cells, MLSR triggers mitophagy and maintains positive autophagic flux through RIP1/RIP3 pathway inhibition.
Nisha Wang +12 more
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Microglial GPR35 Ameliorates Epileptogenesis and Neuroinflammation via PDGFA Domain 2 Signaling
Advanced Science, EarlyView.Activation of microglial G protein–coupled receptor 35 (GPR35) by L‐kynurenic acid (L‐Kyna) initiates a platelet‐derived growth factor A (PDGFA)–dependent phosphoinositide 3‐kinase–protein kinase B (PI3K–AKT) signaling cascade that dampens hippocampal neuroinflammation, thereby restraining epileptogenesis, lowering seizure susceptibility, and ...
Qi Wang +17 more
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Annual Review of Neuroscience, 1995
It is widely assumed that long-term changes in synaptic strength underlie information storage in the brain and, ultimately, behavioral memory. Recent years have seen a major effort to identify and analyze electrophysiological model systems in which particular patterns of neural activity give rise to such enduring changes.
D J, Linden, J A, Connor
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It is widely assumed that long-term changes in synaptic strength underlie information storage in the brain and, ultimately, behavioral memory. Recent years have seen a major effort to identify and analyze electrophysiological model systems in which particular patterns of neural activity give rise to such enduring changes.
D J, Linden, J A, Connor
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Long-Term Depression in Hippocampus
Annual Review of Neuroscience, 1996Long-term depression (LTD) is a lasting decrease in synaptic effectiveness that follows some types of electrical stimulation in the hippocampus. Two broad types of LTD may be distinguished. Heterosynaptic LTD can occur at synapses that are inactive, normally during high-frequency stimulation of a converging synaptic input.
M F, Bear, W C, Abraham
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Annual Review of Neuroscience, 1989
LTD has now been established as a synaptic plasticity specific to the cerebellum. Cellular and molecular mechanisms of LTD have been elucidated to some extent, but still a number of questions are left open. The most crucial question may concern its time course, as to how long the LTD lasts beyond the limit of the present maximum observation time of 3 ...
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LTD has now been established as a synaptic plasticity specific to the cerebellum. Cellular and molecular mechanisms of LTD have been elucidated to some extent, but still a number of questions are left open. The most crucial question may concern its time course, as to how long the LTD lasts beyond the limit of the present maximum observation time of 3 ...
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Long-term management of depression
The American Journal of Medicine, 1994Major depression is often a chronic and recurrent disorder. Findings from a landmark study, the Pittsburgh Study of Maintenance Therapies in Recurrent Depression, demonstrate that full doses of antidepressants prevent recurrent depression and that maintenance therapy lasting at least 5 years may be required for patients with severely recurrent disease.
R M, Hirschfeld, A F, Schatzberg
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Journal of the American Medical Directors Association, 2008
To review the diagnosis and treatment of depressive disorders in long-term care settings.A review of the literature on the diagnosis and treatment of depression in long-term care.Up to 35% of residents in long-term care facilities may experience either major depression or clinically significant depressive symptoms.
Mugdha, Thakur, Dan G, Blazer
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To review the diagnosis and treatment of depressive disorders in long-term care settings.A review of the literature on the diagnosis and treatment of depression in long-term care.Up to 35% of residents in long-term care facilities may experience either major depression or clinically significant depressive symptoms.
Mugdha, Thakur, Dan G, Blazer
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Long-term treatment of depression
European Neuropsychopharmacology, 1994In the late 1800's Kraepelin hypothesized that depression had a high probability for recovery. He described depression as acute episodes from which the patient returned to premorbid state of "well-being". It was postulated that there were subgroups who had a recurrent course, but the emphasis was on the theory that between episodes of depression ...
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Long-Term Depression: Cerebellum
2001Long-term depression (LTD) displayed in the cerebellar cortex is a persistent decrease of the transmission efficacy from granule cell to Purkinje cells. LTD is induced when two inputs to a Purkinje cell, one from a climbing fiber and the other from a set of granule cell axons, are repeatedly associated.
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