Results 31 to 40 of about 4,590,611 (322)

Convergent evidence for abnormal striatal synaptic plasticity in dystonia

Neurobiology of Disease, 2010
Dystonia is a functionally disabling movement disorder characterized by abnormal movements and postures. Although substantial recent progress has been made in identifying genetic factors, the pathophysiology of the disease remains a mystery.
David A. Peterson, Terrence J. Sejnowski, Howard Poizner   +2 more
doaj   +1 more source

Long Term Potentiation (LTP) and Long Term Depression (LTD) Cause Differential Spatial Redistribution of the Synaptic Vesicle Protein Synaptophysin in the Middle Molecular Layer of the Dentate Gyrus in Rat Hippocampus [PDF]

, 2016
The presynaptic modifications that accompany long-term changes in synaptic plasticity are still not fully understood. Synaptophysin is a major synaptic vesicle protein involved in neurotransmitter release. We have used quantitative electron microscopy to
Chaudhury, Sraboni, Dallérac, Glenn, Davies, Heather A., Doyère, Valérie, Kraev, Igor V., Stewart, Michael G.   +5 more
core   +1 more source

Long-term habituation of the gill-withdrawal reflex in Aplysia requires gene transcription, calcineurin and L-type voltage-gated calcium channels

Frontiers in Behavioral Neuroscience, 2010
Although habituation is possibly the simplest form of learning, we still do not fully understand the neurobiological basis of habituation in any organism.
Joseph eEsdin, Kaycey Pearce, David L Glanzman   +2 more
doaj   +1 more source

Medication use in pregnancy: a cross-sectional, multinational web-based study [PDF]

, 2014
Objectives: Intercountry comparability between studies on medication use in pregnancy is difficult due to dissimilarities in study design and methodology. his study aimed to examine patterns and factors associated with medications use in pregnancy from a
Bjornsdottir, I., Drozd, M., Gjergja Juraski, R., Hameen-Anttila, K., Juch, H., Kennedy, D., Lupattelli, A., Mardby, A. C., Moretti, M. E., Nordeng, H., Odalovic, M., Panchaud, A., Passier, A., Rieutord, A., Rudolf, G., Spigset, O., Twigg, M. J., Zagorodnikova, K.   +17 more
core   +5 more sources

NEURONAL SIGNALING

Malang Neurology Journal, 2015
Intracellular processes in neurons begins when the extracellular chemical signals such as neurotransmitters, attached at specific receptors which then activates a cascade of intracellular reactions included herein are proteins GTP, second messengers ...
Shahdevi Nandar Kurniawan
doaj   +1 more source

Uncoupling of the endocannabinoid signalling complex in a mouse model of fragile X syndrome [PDF]

, 2012
Fragile X syndrome, the most commonly known genetic cause of autism, is due to loss of the fragile X mental retardation protein, which regulates signal transduction at metabotropic glutamate receptor-5 in the brain.
DiPatrizio, Nicholas V., Frick, Andreas, Ginger, Melanie, Henstridge, Christopher M., Jung, Kwang-Mook, Katona, Istvan, Lassalle, Olivier, Mackie, Ken, Manzoni, Olivier J., Martin, Henry, Neuhofer, Daniela, Piomelli, Daniele, Sepers, Marja   +12 more
core   +6 more sources

Fluoxetine: a case history of its discovery and preclinical development [PDF]

, 2014
Introduction: Depression is a multifactorial mood disorder with a high prevalence worldwide. Until now, treatments for depression have focused on the inhibition of monoaminergic reuptake sites, which augment the bioavailability of monoamines in the CNS ...
Bel N, Bergstrom RF, Bravo L, Bremner JD, Burrows GD, Chouinard G, Datla KP, Esther Berrocoso, Juan Antonio Mico, Kreiss DS, Laura Perez-Caballero, Lemberger L, Li Q, Lidia Bravo, Maj J, Nibuya M, Owens MJ, Rutter JJ, Sonia Torres-Sanchez, Stevens JC, Wong DT   +20 more
core   +2 more sources

Non-Hebbian Spike-Timing Dependent Plasticity in Cerebellar Circuits

Frontiers in Neural Circuits, 2013
Spike-timing dependent plasticity (STDP) provides a cellular implementation of the Hebb postulate, which states that synapses, whose activity repeatedly drives action potential firing in target cells, are potentiated.
Claire ePiochon, Peter eKruskal, Jason N MacLean, Christian eHansel   +3 more
doaj   +1 more source

Early clinical predictors and correlates of long-term morbidity in bipolar disorder [PDF]

, 2017
OBJECTIVES: Identifying factors predictive of long-term morbidity should improve clinical planning limiting disability and mortality associated with bipolar disorder (BD).
Baldessarini, R. J., DE CHIARA, Lavinia, Girardi, Paolo, Koukopoulos, A. E., Koukopoulos, Alexia, Reginaldi, D., Sani, Gabriele, Serra, Giulia, Tondo, L.   +8 more
core   +1 more source

Neo-synthesis of estrogenic or androgenic neurosteroids determine whether long-term potentiation or depression is induced in hippocampus of male rat

Frontiers in Cellular Neuroscience, 2015
Estrogenic and androgenic steroids synthesized in the brain may rapidly modulate synaptic plasticity interacting with specific membrane receptors. We explored by electrophysiological recordings in hippocampal slices of male rat the influence of 17b ...
Michela eDi Mauro, Alessandro eTozzi, Alessandro eTozzi, Paolo eCalabresi, Paolo eCalabresi, Vito Enrico Pettorossi, Silvarosa eGrassi   +6 more
doaj   +1 more source