Results 71 to 80 of about 4,459,968 (325)

Practice Recommendations for Genetic Testing of Ataxias

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Over the past decade, significant advances in genetic testing for ataxia have improved diagnostic accuracy, informed clinical trial eligibility, guided treatment decisions, and enabled cascade testing of at‐risk relatives. While guidance exists for other neurogenetic conditions, there are no standardized guidelines on genetic ...
Sharan R. Srinivasan, Amy D. Mook, Michelle Rochman, Jin Yun Helen Chen, Weiyi Mu, George R. Wilmot, Liana S. Rosenthal, Wendy R. Uhlmann   +7 more
wiley   +1 more source

The role of astrocytic aquaporin-4 in synaptic plasticity and learning and memory

Frontiers in Integrative Neuroscience, 2016
Aquaporin-4 (AQP4) is the predominant water channel expressed by astrocytes in the central nervous system. AQP4 is widely expressed throughout the brain, especially at the blood-brain barrier where AQP4 is highly polarized to astrocytic foot processes ...
Jenny I. Szu, Devin K. Binder
doaj   +1 more source

A Randomized Depression Prevention Trial Comparing Interpersonal Psychotherapy—Adolescent Skills Training To Group Counseling In Schools [PDF]

, 2016
Given the rise in depression disorders in adolescence, it is important to develop and study depression prevention programs for this age group. The current study examined the efficacy of Interpersonal Psychotherapy-Adolescent Skills Training (IPT-AST), a ...
Benas, J. S., Gallop, R., Gillham, Jane, Mufson, L., Schueler, C. M., Young, J. F.   +5 more
core   +1 more source

Input-specific maturation of synaptic dynamics of parvalbumin interneurons in primary visual cortex [PDF]

, 2014
Cortical networks consist of local recurrent circuits and long-range pathways from other brain areas. Parvalbumin-positive interneurons (PVNs) regulate the dynamic operation of local ensembles as well as the temporal precision of afferent signals.
Huang, Z. J., Lin, Y., Lu, J., Tucciarone, J.   +3 more
core   +1 more source

Cognitive Impairment in Multiple Sclerosis: The Role of Clinical and Sociodemographic Factors ‐ A Systematic Review and Meta‐Analysis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Cognitive impairment (CI) affects the quality of life in multiple sclerosis (MS). Identifying influencing factors is key to improving CI monitoring. This systematic review and meta‐analysis examines clinical and sociodemographic variables impacting the cognitive screening Symbol Digit Modalities Test (SDMT) performance across MS ...
Katalin Lugosi, Marie A. Engh, Tamás Kói, Zsolt Molnár, Gábor Csukly, Klaudia Horváth, Emma Hargitai, Péter Hegyi, Zsolt Mezei   +8 more
wiley   +1 more source

Multiple forms of metaplasticity at a single hippocampal synapse during late postnatal development

Developmental Cognitive Neuroscience, 2015
Metaplasticity refers to adjustment in the requirements for induction of synaptic plasticity based on the prior history of activity. Numerous forms of developmental metaplasticity are observed at Schaffer collateral synapses in the rat hippocampus at the
Daniel G. McHail, Theodore C. Dumas
doaj   +1 more source

Plasma Glial Fibrillary Acidic Protein Correlates With Brain Metal Burden in Wilson's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Neuroinflammation driven by extracellular copper contributes to neuronal damage in Wilson's disease (WD). This study investigated the relationship between brain metal burden and peripheral neuroinflammation markers in WD. Methods We conducted a cross‐sectional study involving 89 participants, including patients with WD (n = 63 ...
Sung‐Pin Fan, Ya‐Fang Chen, Cheng‐Hsuan Li, Yih‐Chih Kuo, Ni‐Chung Lee, Yin‐Hsiu Chien, Wuh‐Liang Hwu, Tai‐Chung Tseng, Tung‐Hung Su, Chien‐Ting Hsu, Huey‐Ling Chen, Chin‐Hsien Lin, Yen‐Hsuan Ni   +12 more
wiley   +1 more source

Climbing fiber signaling and cerebellar gain control

Frontiers in Cellular Neuroscience, 2009
The physiology of climbing fiber signals in cerebellar Purkinje cells has been studied since the early days of electrophysiology. Both the climbing fiber-evoked complex spike and the role of climbing fiber activity in the induction of long-term ...
Gen Ohtsuki, Gen Ohtsuki, Claire Piochon, Christian Hansel, Christian Hansel   +4 more
doaj   +1 more source

The self-management of longer-term depression: learning from the patient, a qualitative study [PDF]

, 2015
Background Depression is a common mental health condition now viewed as chronic or long-term. More than 50 % of people will have at least one further episode of depression after their first, and therefore it requires long-term management.
A Coulter, A Faulkner, A Giorgi, A Holzinger, AF Jorm, AJ Morgan, Alexis Foster, Anna Thake, B Schrank, C Chew-Graham, C Johnson, C McDonald, D Richards, DJ Kupfer, DV Sheehan, E Fossey, E Marley, Eleni Chambers, G Lewis, G Shepherd, Glenys Parry, J Aked, J Barlow, J Gellatly, J Houle, J Kalathil, J Wallcraft, JA Smith, JA Smith, KE Biesheuvel-Leliefeld, L Davidson, L Finlay, LJ Barney, M Larkin, M Lucock, N Mays, N Mays, National Collaborating Centre for Mental Health: Depression, P Bower, PC Boer den, R Pratt, R Shaw, RA Grieken van, Rebecca Hutten, S Allam, S Bonney, S Gillard, S Martindale, S Newman, S Pilling, Sarah Cook, Sue Shaw, T Stickley, T Stickley, TM Harwood, Tom Ricketts, V Braun   +56 more
core   +1 more source

Exploring Nasal Structural‐Microbial Interactions in Multiple Sclerosis‐Associated Olfactory Impairment

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Olfactory dysfunction is frequently observed in patients with multiple sclerosis (MS); however, its underlying mechanisms remain poorly understood. To date, no studies have directly examined the nasal mucosal microbiota in MS. This study aimed to explore potential relationships among olfactory function, nasal microbiota composition,
Zidan Gao, Zhuoma Danzhen, Yao Li, Junyu Zhu, Lan Chu, Zhang Yang   +5 more
wiley   +1 more source