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Proteases involved in long-term potentiation
Life Sciences, 2002Much attention has been paid to proteases involved in long-term potentiation (LTP). Calpains, Ca-dependent cysteine proteases, have first been demonstrated to be the mediator of LTP by the proteolytic cleavage of fodrin, which allows glutamate receptors located deep in the postsynaptic membrane to move to the surface.
Shigenori Watanabe +4 more
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THE HIPPOCAMPUS, LONG‐TERM POTENTIATION AND MEMORY
Clinical and Experimental Pharmacology and Physiology, 1996SUMMARY1. The induction of long‐term potentiation (LTP) at excitatory synapses on CA1 pyramidal neurons occurs partly through an increase in the quantal AMPA current. It is also accompanied by an increase in the number of active sites. Any presynaptic modification, requiring the presence of a retrograde messenger, remains uncertain.2.
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Long-term potentiation in spinothalamic neurons
Brain Research Reviews, 2002Sensitization of nociceptive dorsal horn neurons, including spinothalamic tract (STT) cells, is thought to underlie the development of secondary hyperalgesia and allodynia following tissue injury. In central sensitization, responses to stimulation of sensory receptors are enhanced without any change in the excitability of the primary afferent neurons ...
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Long-Term Potentiation and Memory
1989Long-term potentiation (LTP) is an enduring change in synaptic efficacy at monosynaptic junctions in the mammalian brain. LTP was first observed in the hippocampus, in area CAI and the dentate gyrus. The link between LTP and hippocampus is well established and suggests a role for LTP in learning and memory, as is widely hypothesized for the hippocampus.
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Long-Term Potentiation as a Model
1995Long-term potentiation (LTP) is a strengthening of synaptic transmission that was first discovered in the hippocampus (Bliss and Lomo, 1973). If one stimulates the afferents to the hippocampus at a high rate (100 Hz for 3 sec), the excitatory postsynaptic potentials in the hippocampal pyramidal cells are subsequently found to be larger than normal, and
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Long-term potentiation and long-term depression in the neocortex
Progress in Neurobiology, 1992openaire +3 more sources
The current excitement in long term potentiation
Neuron, 1988Roger A. Nicoll +2 more
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