Results 291 to 300 of about 3,183,091 (359)

Compact Optical Reservoir Computing via Luminescence Dynamics in Rare‐Earth Ions‐Doped Nanocrystals

open access: yesAdvanced Science, EarlyView.
A functionally compact optical reservoir computing platform is demonstrated using rare‐earth ion‐doped nanocrystals, whose intrinsic nonlinear luminescence dynamics and multi‐timescale metastable states provide nonlinear mapping and fading memory without bulky delays or resonant structures.
Junyan Chen   +7 more
wiley   +1 more source

Integrin β3 Orchestrates Hepatic Steatosis via a Novel CD36‐Dependent Lipid Uptake Complex

open access: yesAdvanced Science, EarlyView.
In MASH, ITGB3 recruits LYN and drives its ubiquitin‐proteasomal degradation via phosphorylation. This relieves DHHC5 inhibition, enabling ITGB3/DHHC5/CD36 complex assembly to enhance CD36 palmitoylation and fatty acid uptake, thereby exacerbating disease. Targeting ITGB3 blocks this pathogenic axis and ameliorates MASH.
Ying Zhang   +13 more
wiley   +1 more source

Rapidly reversible persistent long-term potentiation inhibition by patient-derived brain tau and amyloid ß proteins. [PDF]

open access: yesPhilos Trans R Soc Lond B Biol Sci
Ondrejcak T   +6 more
europepmc   +1 more source

Multifunctional Nano Immunostimulant: Overcoming Immunosuppressive Microenvironment for Antitumor Immunotherapy

open access: yesAdvanced Science, EarlyView.
A multifunctional nano immunostimulant is first proposed for efficient tumor immunotherapy. The ER targeted ability, superior ROS production, efficient GSH consumption, coupled with the HIF suppression, jointly arouses ICD/ferroptosis pathways to realize efficient tumor immunotherapy.
Guanhong Guo   +14 more
wiley   +1 more source

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