Targeting Synaptic Plasticity in Experimental Models of Alzheimer’s Disease
Frontiers in Pharmacology, 2019 Long-term potentiation (LTP) and long-term depression (LTD) of hippocampal synaptic transmission represent the principal experimental models underlying learning and memory.
Dalila Mango +7 more
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Hardware Implementation of On‐Chip Hebbian Learning Through Integrated Neuromorphic Architecture
Advanced Materials, EarlyView.This work presents a neuromorphic hardware platform that integrates presynaptic transistors, threshold switching neurons, and adaptive feedback synapses. The architecture enables on‐chip Hebbian learning through correlation‐based weight updates without external training circuits.
Seonkwon Kim +6 more
wiley +1 more source
The two major phosphoproteins in growth cones are probably identical to two protein kinase C substrates correlated with persistence of long- term potentiation [PDF]
, 1989 RB Nelson +4 more
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Postsynaptic factors in the expression of long-term potentiation (LTP): increased glutamate receptor binding following LTP induction in vivo. [PDF]
, 1993 Stephen Maren +4 more
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The role of astrocytic aquaporin-4 in synaptic plasticity and learning and memory
Frontiers in Integrative Neuroscience, 2016 Aquaporin-4 (AQP4) is the predominant water channel expressed by astrocytes in the central nervous system. AQP4 is widely expressed throughout the brain, especially at the blood-brain barrier where AQP4 is highly polarized to astrocytic foot processes ...
Jenny I. Szu, Devin K. Binder
doaj +1 more source
Advanced Materials, EarlyView.The development of an energy‐efficient and biologically inspired spiking neuron device based on a CuInP2S6 (CIPS) ferroionic threshold switching field‐effect transistor TS‐FET is reported. The device demonstrates essential neuronal behaviors, such as leaky integrate‐and‐fire dynamics, a tunable firing threshold, and spatiotemporal processing, all ...
Sungpyo Baek +6 more
wiley +1 more source
Motor cortical plasticity induced by motor learning through mental practice.
Frontiers in Behavioral Neuroscience, 2015 Several investigations suggest that actual and mental actions trigger similar neural substrates. Motor learning via physical practice results in long-term potentiation (LTP)-like plasticity processes, namely potentiation of M1 and a temporary occlusion ...
Laura eAvanzino +5 more
doaj +1 more source
Advances and Strategies in Enhancing mRNA Cancer Vaccines
Advanced Materials, EarlyView.Messenger RNA (mRNA) vaccines offer a powerful approach for cancer immunotherapy, but their clinical impact remains limited by delivery challenges and suboptimal immune activation. This review discusses key biological barriers and design strategies—including structural optimization, immunomodulation, organ targeting delivery, and advanced nanocarriers ...
Miao Zhang +4 more
wiley +1 more source
Elevation of intracellular calcium content in area CA1 of hippocampus is not directly correlated with the development of long-term potentiation [PDF]
, 1989 L. Siklós +3 more
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Advanced Biomedical ResearchBackground: Escitalopram, a pharmacological compound, and crocin, the active compound of saffron, influence brain functions and serotonin levels. This study examined the efficacy of escitalopram with and without crocin in restoring the input-output (I/O)
Mehran Joodaki +2 more
doaj +1 more source