Results 31 to 40 of about 10,137,229 (249)
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Long Term Care Ombudsman Annual Report 1993
, 1993 October, 1992 through September 30 ...
Kansas. Long Term Care Ombudsman
core +1 more source
Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network
FEBS Letters, EarlyView.Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley +1 more source
EMPIRICAL STRENGTH CRITERION OF COMPOSITE MATERIALS
Advanced Engineering Research, 2010 Empirical long-term strength criterion in terms of limit stress for constructive polymer materials considering ageing factor is found. The criterion corresponds to the type of Goldenblat - Kopnov.
O.G. OSYAEV
doaj
Prospecting the protein design landscape
FEBS Letters, EarlyView.This review outlines the current state of various protein design approaches. We discuss the current possibilities enabled by recently released tools, highlight future avenues to pursue in protein design, and underscore the crucial role of key databases and resources for successful protein design workflows.
Jakob R. Riccabona +4 more
wiley +1 more source
EMPIRICAL STRENGTH CRITERION OF COMPOSITE MATERIALS
Вестник Донского государственного технического университета, 2018 Empirical long-term strength criterion in terms of limit stress for constructive polymer materials considering ageing factor is found. The criterion corresponds to the type of Goldenblat - Kopnov.
O.G. OSYAEV
doaj
Artificial molecular machines and motors—Design and control of nanoscale motion
FEBS Letters, EarlyView.Molecules are constantly moving because of thermal fluctuations, but random motion alone cannot be exploited to perform directional tasks. Artificial molecular machines use chemical, electrical, or light energy to bias this motion. Molecular shuttles, rotary motors, and supramolecular pumps illustrate how nanoscale movement can be controlled and ...
Leonardo Andreoni, Alberto Credi
wiley +1 more source
CRITERIAL METHOD OF CALCULATIONS OF LONG-TERM STABILITY OF THE BOREHOLE
Известия высших учебных заведений: Нефть и газ, 2018 The article examines the possibility of applying the Mohr - Coulomb short-term strength criterion to the calculations of long-term stability of open oil wells. The results of calculation of long-term and short-term strength on the basis of the polygon of
O. A. Shipilova, S. V. Shafieva
doaj +1 more source
FEBS Letters, EarlyView.Transient oligomers formed by intrinsically disordered proteins may be ‘invisible’ to direct detection yet remain accessible to solution NMR through equilibrium‐exchange measurements and pressure‐jump experiments. Complementary methods report on mass, stoichiometry, selected distance distributions, morphology, and internal packing.
Martin D. Gelenter, Ad Bax
wiley +1 more source