Results 41 to 50 of about 10,137,229 (249)
Molecular Oncology, EarlyView.Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim +3 more
wiley +1 more source
Long Term Care Ombudsman Annual Report, 2002
, 2003 October 1, 2002 to September 30 ...
Kansas. Long Term Care Ombudsman
core +1 more source
Molecular Oncology, EarlyView.Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley +1 more source
ANALYSIS LAYER MODEL OF POLYMER COMPOSITE DESIGN UNDER MULTIFACTOR LOADING
Вестник Донского государственного технического университета, 2018 A mathematical model is offered for the analysis of complex stress-strain state of the layer load-carrying structures of the aircraft planes. It is presented as sets of the equations of the constraining relations of load parameters, voltages and ...
Oleg G. Osyaev +3 more
doaj
The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer
Molecular Oncology, EarlyView.Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad +2 more
wiley +1 more source
Models for Predicting the Long-Term Strength of Rheonomic Materials
Applied SciencesReliable modeling and prediction of the long-term strength of materials are relevant, as they allow for accurate determination of the service life of structures and components made from these materials.
Alibay Iskakbayev +4 more
doaj +1 more source
Experimental Investigation on the Post-Peak Short-Term and Creep Behavior of Fractured Sandstone
Energies, 2020 Short-term and creep tests of fractured sandstone with different degrees of damage prepared using pre-peak and post-peak unloading tests on intact sandstone were carried out using a servo-controlled rock mechanics system.
Yijiang Zong +4 more
doaj +1 more source
Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae
FEBS Open Bio, EarlyView.Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj +3 more
wiley +1 more source
Слобожанський науково-спортивний вісникBackground and Study Aim. Considering that there are no studies aimed at identifying the components of physical and functional fitness in arm wrestling at the stage of preliminary basic training, and it is not advisable to transfer training of adult ...
Dmytro Bezkorovainyi +5 more
doaj +1 more source
Delivery of DNA‐encoded vaccines and proteins in mice using cutaneous suction‐mediated transfection
FEBS Open Bio, EarlyView.Cutaneous suction‐mediated transfection in mice for delivery of DNA‐encoded vaccines and proteins. A critical limitation of DNA vaccines and other therapeutics is transfection in vivo to produce the encoded antigens or therapeutic proteins. Cutaneous suction‐based methods have demonstrated effectiveness in many animal models and have been successfully ...
Emran O. Lallow +12 more
wiley +1 more source