Results 11 to 20 of about 1,557 (133)

Engineering of 1,4-Butanediol and Adipic Acid Metabolism in Pseudomonas taiwanensis for Upcycling to Aromatic Compounds. [PDF]

Microb Biotechnol
Growth of an aromatics‐overproducing Pseudomonas taiwanensis on adipate and 1,4‐butanediol was engineered for bio‐upcycling. Adaptive laboratory evolution followed by genome sequencing was used to identify and reverse engineer growth‐enabling mutations.
Op de Hipt L, Ackermann YS, de Jong H, Polen T, Wynands B, Wierckx N.   +5 more
europepmc   +2 more sources

CRISPR/Cas9-Mediated Gene Knockout in Cereal Crops. [PDF]

Curr Protoc
Abstract High‐precision genome editing tools, such as programmable nucleases, are poised to transform crop breeding and significantly impact fundamental plant research. Among these tools, the CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats)/Cas9 (CRISPR‐associated 9) system is a programmable, RNA‐guided nuclease that introduces ...
Pramanik D, Wang K, Lee K.
europepmc   +2 more sources

LINC01426 aggravates the malignant progression of glioma through miR-661/Mdm2 axis

Brain Research Bulletin, 2022
Background: Long intergenic non-protein coding RNA 1426 (LINC01426) is up-regulated in glioma and functions as a tumor promoter. However, the role of LINC01426 in glioma required further exploration.
Bo Shu, Hongchuan Gan, Cheng Wang, Chunan Cao, Hui Tong, Dan Liang   +5 more
doaj   +1 more source

Upregulation of LINC01426 promotes the progression and stemness in lung adenocarcinoma by enhancing the level of SHH protein to activate the hedgehog pathway

Cell Death and Disease, 2021
Long noncoding RNAs (lncRNAs) play crucial roles in regulating a variety of biological processes in lung adenocarcinoma (LUAD). In our study, we mainly explored the functional roles of a novel lncRNA long intergenic non-protein coding RNA 1426 (LINC01426)
Xiaoli Liu, Zuwei Yin, Linping Xu, Huaimin Liu, Lifeng Jiang, Shuochuan Liu, Xu Sun   +6 more
doaj   +1 more source

The genome sequence of a spider mite, Tetranychus truncatus, provides insights into interspecific host range variation and the genetic basis of adaptation to a low‐quality host plant

Insect Science, Volume 30, Issue 5, Page 1208-1228, October 2023., 2023
The phytophagous mite Tetranychus truncatus is a significant pest in East Asia, but its host range is relatively narrower than that of Tetranychus urticae, another pest mite. We have produced a high‐quality, chromosomal‐level genome of T. truncatus and compared it with that of T. urticae. Our findings indicate that T.
Lei Chen, Xin‐Yue Yu, Xiao‐Feng Xue, Feng Zhang, Li‐Xue Guo, Hua‐Meng Zhang, Ary A. Hoffmann, Xiao‐Yue Hong, Jing‐Tao Sun   +8 more
wiley   +1 more source

A Long Intergenic Non-coding RNA, LINC01426, Promotes Cancer Progression via AZGP1 and Predicts Poor Prognosis in Patients with LUAD

Molecular Therapy: Methods & Clinical Development, 2020
Various long non-coding RNAs (lncRNAs) are closely associated with lung adenocarcinoma (LUAD), playing oncogenic or anti-oncogenic roles in tumorigenesis and progression.
Baorui Tian, Xiaoyang Han, Guanzhen Li, Hua Jiang, Jianni Qi, Jiamei Li, Yingying Tian, Chuanxi Wang   +7 more
doaj   +1 more source

Genomic and proteomic biases inform metabolic engineering strategies for anaerobic fungi. [PDF]

, 2020
Anaerobic fungi (Neocallimastigomycota) are emerging non-model hosts for biotechnology due to their wealth of biomass-degrading enzymes, yet tools to engineer these fungi have not yet been established.
Albà, Arazoe, Atasoglu, Bach, Beckham, Bezanson, Birdsell, Boch, Bonugli-Santos, Brownlee, Calkins, Camacho, Camiolo, Carlson, Chan, Chen, Cheng, Cheng, Chokhawala, Coker, Deshpande, Diener, Dollhofer, Duarte, Durand, Duret, Fondon, Galtier, Gasiunas, Gentzsch, Gerngross, Glass, Glémin, Greene, Grigoriev, Haitjema, Haitjema, Hamilton, Hanafy, Hartfield, Henske, Hershberg, Hildebrand, Hull, Jiang, Karlin, Kiktev, Kleinstiver, Kleinstiver, Knauer, Knight, Kuyper, Leberer, Li, Liggenstoffer, Liu, Magee, Mertens, Meunier, Morrison, Murphy, Nicholson, Nieuwenhuis, Nørholm, Orpin, Oyola, O’Malley, Podolsky, Raymond, Reichenberger, Ropars, Sadhu, Sammond, Sekowska, Seppälä, Seppälä, Solieri, Solomon, Sonan, Staben, Steensels, Steensels, Sukumaran, Theodorou, UniProt: a worldwide hub of protein knowledge, Videvall, Wang, Wang, Wright, Wu, Ximenes, Youssef, Zetsche   +92 more
core   +1 more source

Effect of shear stress on Pseudomonas aeruginosa isolated from the cystic fibrosis lung [PDF]

, 2016
Chronic colonization of the lungs by Pseudomonas aeruginosa is one of the major causes of morbidity and mortality in cystic fibrosis (CF) patients. To gain insights into the characteristic biofilm phenotype of P. aeruginosa in the CF lungs, mimicking the
Cornelis, Pierre, Crabbé, Aurélie, Dingemans, Jozef, Förstner, Konrad U, Malfroot, Anne, Monsieurs, Pieter, Van Houdt, Rob, Yu, Sung-Huan   +7 more
core   +7 more sources

Interaction and cross-talk between non-coding RNAs. [PDF]

, 2017
Non-coding RNA (ncRNA) has been shown to regulate diverse cellular processes and functions through controlling gene expression. Long non-coding RNAs (lncRNAs) act as a competing endogenous RNAs (ceRNAs) where microRNAs (miRNAs) and lncRNAs regulate each ...
Dahiya, Rajvir, Imai-Sumida, Mitsuho, Tanaka, Yuichiro, Yamamura, Soichiro   +3 more
core   +2 more sources

Peptidomic discovery of short open reading frame-encoded peptides in human cells [PDF]

, 2014
The amount of the transcriptome that is translated into polypeptides is of fundamental importance. We developed a peptidomic strategy to detect short ORF (sORF)-encoded polypeptides (SEPs) in human cells. We identified 90 SEPs, 86 of which are novel, the
Budnik, Bogdan A., Cabili, Moran N., Karger, Amir, Levin, Joshua Z., Ma, Jiao, Mitchell, Andrew J., Rinn, John L., Saghatelian, Alan, Schwaid, Adam G., Slavoff, Sarah A.   +9 more
core   +1 more source