Evolution of transcriptional enhancers and animal diversity [PDF]
, 2013 Deciphering the genetic bases that drive animal diversity is one of the major challenges of modern biology. Although four decades ago it was proposed that animal evolution was mainly driven by changes in cis-regulatory DNA elements controlling gene ...
Rubinstein, Marcelo +1 more
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Expression of down-regulated ERV LTR elements associates with immune activation in human small-cell lung cancers [PDF]
, 2023 Small-cell lung cancer (SCLC) is an aggressive cancer characterized by immunosuppressive features leading to poor responses to current immunotherapies.
Capranico, Giovanni +2 more
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Role of long non-coding RNAs in adipose tissue metabolism and associated pathologies [PDF]
, 2023 The incidence of obesity and its related disorders has increased dramatically in recent years and has become a pandemic. Adipose tissue is a crucial regulator of these diseases due to its endocrine capacity.
Alcala, Martín +8 more
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Deep-sequencing of endothelial cells exposed to hypoxia reveals the complexity of known and novel microRNAs [PDF]
, 2012 In order to understand the role of microRNAs (miRNAs) in vascular physiopathology, we took advantage of deep-sequencing techniques to accurately and comprehensively profile the entire miRNA population expressed by endothelial cells exposed to hypoxia ...
Brini, Elena +11 more
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Advances with long non-coding rnas in alzheimer’s disease as peripheral biomarker [PDF]
, 2021 One of the most compelling needs in the study of Alzheimer’s disease (AD) is the characterization of cognitive decline peripheral biomarkers. In this context, the theme of altered RNA processing has emerged as a contributing factor to AD.
Cereda C. +5 more
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Characterization of novel bacteriophages for biocontrol of bacterial blight in leek caused by Pseudomonas syringae pv. porri [PDF]
, 2016 Pseudomonas syringae pv. porri, the causative agent of bacterial blight in leek (Allium porrum), is increasingly frequent causing problems in leek cultivation. Because of the current lack of control measures, novel bacteriophages were isolated to control
Anneleen eVolckaert +16 more
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Translational implications of the β-cell epigenome in diabetes mellitus [PDF]
, 2015 Diabetes mellitus is a disorder of glucose homeostasis that affects more than 24 million Americans and 382 million individuals worldwide. Dysregulated insulin secretion from the pancreatic β cells plays a central role in the pathophysiology of all forms ...
Evans-Molina, Carmella +1 more
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SalmoNet, an integrated network of ten Salmonella enterica strains reveals common and distinct pathways to host adaptation [PDF]
, 2017 Salmonella enterica is a prominent bacterial pathogen with implications on human and animal health. Salmonella serovars could be classified as gastro-intestinal or extra-intestinal.
A Chatr-Aryamontri +97 more
core +3 more sources
c-Myc activates BRCA1 gene expression through distal promoter elements in breast cancer cells [PDF]
, 2011 Background The BRCA1 gene plays an important role in the maintenance of genomic stability. BRCA1 inactivation contributes to breast cancer tumorigenesis.
Yinghua Chen +5 more
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piRNA pathway targets active LINE1 elements to establish the repressive H3K9me3 mark in germ cells [PDF]
, 2014 Transposable elements (TEs) occupy a large fraction of metazoan genomes and pose a constant threat to genomic integrity. This threat is particularly critical in germ cells, as changes in the genome that are induced by TEs will be transmitted to the next ...
Aravin, Alexei A. +3 more
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