Results 61 to 70 of about 9,101,712 (212)

The trimeric Shu complex in C. elegans is an ATPase that remodels RAD51 filaments in the homologous recombination‐associated DNA damage response

The FEBS Journal, EarlyView.
The C. elegans Shu complex (RFS‐1/RIP‐1/SWS‐1) is a DNA‐dependent ATPase that regulates RAD‐51 filaments during homologous recombination. The trimer preferentially binds 5′‐exposed DNA, remodels RAD‐51 filaments via ATP hydrolysis, and stabilizes filaments through ATP binding.
Sam Siu Hang Chu, Guangxin Xing, Kichang Paik, Anton Gartner, Hong Ling   +4 more
wiley   +1 more source

Involvement of retrotransposition of long interspersed nucleotide element‐1 in skin tumorigenesis induced by 7,12‐dimethylbenz[a]anthracene and 12‐O‐tetradecanoylphorbol‐13‐acetate

Cancer Science, 2011
Tumor development induced by 7,12‐dimethylbenz[a]anthracene (DMBA) plus 12‐O‐tetradecanoylphorbol‐13‐acetate (TPA) is a well‐characterized model of multistep carcinogenesis. DMBA mutates the Ha‐ras gene, whereas TPA promotes the growth of transformed cells by activating cellular signaling molecules. It remains to be clarified how repeated TPA treatment
Noriyuki, Okudaira, Motohito, Goto, Rieko, Yanobu-Takanashi, Masato, Tamura, Akihiro, An, Yukiko, Abe, Shigeyuki, Kano, Shotaro, Hagiwara, Yukihito, Ishizaka, Tadashi, Okamura   +9 more
openaire   +2 more sources

Is urbanisation a barrier to genetic diversity in the solitary specialist bee, Melissodes druriellus?

Insect Conservation and Diversity, EarlyView.
Bees are integral pollinators commonly found in and supported by urban green spaces; however, their eco‐evolutionary response to urbanisation varies interspecifically. While several studies have explored the population and landscape genetics of bees in response to urbanisation, few have examined solitary or specialist species which may be more ...
Anthony C. Ayers, Sargon Yousefian Dezag Tekkie, S. Eryn McFarlane, Sandra M. Rehan   +3 more
wiley   +1 more source

Cofactor regeneration by a soluble pyridine nucleotide transhydrogenase for biological production of hydromorphone [PDF]

, 2000
We have applied the soluble pyridine nucleotide transhydrogenase of Pseudomonas fluorescens to a cell-free system for the regeneration of the nicotinamide cofactors NAD and NADP in the biological production of the important semisynthetic opiate drug ...
French, C E, Walker, E H, Bruce, N C, Rathbone, D A, Boonstra, B   +4 more
core   +1 more source

Genome assembly of Elcysma westwoodi provides insights into host‐plant cyanogenic glucoside detoxification and chemical defence gene evolution

Insect Molecular Biology, EarlyView.
A chromosome‐level genome of Elcysma westwoodi was assembled. The genome encodes 272 detoxification‐related genes. A single‐copy bCAS was retained for cyanide detoxification. CYP405A and CYP332A were recruited into cyanogenic defence evolution. UGT33A retained a conserved GT‐B fold and catalytic domains.
Minyoung Choi, Murtaza Khan, Juil Kim
wiley   +1 more source

Effects of the Hypomethylating Agent Guadecitabine on Peripheral Blood Mononuclear Cell Methylomes and Immune Cell Populations in Small-Cell Lung Cancer Patients

Pharmaceuticals
Background/Objectives: Epigenetic modifications, particularly DNA methylation, contribute to tumor progression and therapy resistance. Guadecitabine, a hypomethylating agent (HMA), has shown promising clinical activity when combined with carboplatin in ...
Elnaz Abbasi Farid, Shu Zhang, Zhen Fu, Collin M. Coon, Daniela Matei, Shadia I. Jalal, Kenneth P. Nephew   +6 more
doaj   +1 more source

Additional file 6: Figure S3. of Prognostic and predictive significance of long interspersed nucleotide element-1 methylation in advanced-stage colorectal cancer

, 2016
Influence of clinical and histopathological parameters and of tumor LINE-1 methylation levels on the OS of patients was analyzed by Kaplan-Meier analysis. Levels of tumor LINE-1 methylation were classified as high or low based on the cutoff value (51.7%) determined by the ROC curve (Fig. 3a). (PPTX 664 kb)
Kaneko, Mami, Kotake, Masanori, Bando, Hiroyuki, Yamada, Tetsuji, Takemura, Hirofumi, Toshinari Minamoto   +5 more
openaire   +1 more source

Assessment of global long interspersed nucleotide element‐1 ( LINE ‐1) DNA methylation in a longitudinal cohort of type 2 diabetes mellitus (T2 DM ) individuals

International Journal of Clinical Practice, 2018
Recent studies have indicated that methylation of the LINE-1 elements is associated with an increased risk of worsening carbohydrate metabolism. It has been shown that overall DNA methylation of LINE-1 elements could be considered as a risk factor for T2DM and its complications, independent of other established risk factors.A total of 794 T2DM ...
Nagaraj Malipatil, Mark Lunt, Ram Prakash Narayanan, Kirk Siddals, Gabriela Y Cortés Moreno, Martin J. Gibson, Harvest F. Gu, Adrian H. Heald, Rachelle P. Donn   +8 more
openaire   +5 more sources

Genes, fish and fisheries: translating science into policy

Journal of Fish Biology, EarlyView.
Abstract The 2024 Annual Symposium of the Fisheries Society of the British Isles reviewed the burgeoning impact of ‘omics’ technologies on fish ecology, management and forecasting. As with life sciences more generally, major advances in speed, cost‐effectiveness and breadth of applications in ‘omics’ has had profound societal and environmental impacts.
Gary R. Carvalho
wiley   +1 more source

Additional file 7: Figure S4. of Prognostic and predictive significance of long interspersed nucleotide element-1 methylation in advanced-stage colorectal cancer

, 2016
Comparison of LINE-1 scores determined by FAIRE in LINE-1-expressing (SW480, Caco2) and non-expressing (HCT116, RKO) colon cancer cells that were treated with or without 2 ÎźM oxaliplatin for 2 hrs. The primer set (2) (Additional file 1: Table S1) was used for FAIRE analysis. (PPTX 38 kb)
Kaneko, Mami, Kotake, Masanori, Bando, Hiroyuki, Yamada, Tetsuji, Takemura, Hirofumi, Minamoto, Toshinari   +5 more
openaire   +1 more source