Results 41 to 50 of about 9,101,712 (212)

Differential LINE-1 Hypomethylation of Gastric Low-Grade Dysplasia from High Grade Dysplasia and Intramucosal Cancer

Gut and Liver, 2011
Background/AimsGastric epithelial dysplasia is considered a precancerous lesion with a variable clinical course. There is disagreement, however, regarding histology-based diagnoses, which has led to confusion in choosing a therapeutic plan. New objective
doaj   +1 more source

Prognostic significance of LINE-1 hypomethylation in oropharyngeal squamous cell carcinoma

Clinical Epigenetics, 2017
Background Inclusion of new biomarkers to improve a personalized treatment approach for oropharyngeal squamous cell carcinoma (OPSCC) is urgently needed. Hypomethylation of the Long interspersed nucleotide element-1 (LINE-1) repetitive elements, a widely
Carlo Furlan, Jerry Polesel, Luigi Barzan, Giovanni Franchin, Sandro Sulfaro, Salvatore Romeo, Francesca Colizzi, Aurora Rizzo, Vittorio Baggio, Vittorio Giacomarra, Angelo Paolo Dei Tos, Paolo Boscolo-Rizzo, Emanuela Vaccher, Riccardo Dolcetti, Luca Sigalotti, Elisabetta Fratta   +15 more
doaj   +1 more source

Secretopathies emerge as a new class of neurocristopathies

Developmental Dynamics, EarlyView.
Abstract Neural crest cells are a transient embryonic population of cells that give rise to a wide range of structures, including craniofacial cartilage and bone, peripheral neurons and glia, as well as components of the cardiac outflow tract, among others.
Amanda Teixeira, Cassandra Millet‐Boureima, Joshua A. Moore, Loydie A. Jerome‐Majewska   +3 more
wiley   +1 more source

A lower degree of PBMC L1 methylation in women with lower folate status may explain the MTHFR C677T polymorphism associated higher risk of CIN in the US post folic acid fortification era.

PLoS ONE, 2014
BackgroundStudies in populations unexposed to folic acid (FA) fortification have demonstrated that MTHFR C677T polymorphism is associated with increased risk of higher grades of cervical intraepithelial neoplasia (CIN 2+).
Suguna Badiga, Gary L Johanning, Maurizio Macaluso, Andres Azuero, Michelle M Chambers, Nuzhat R Siddiqui, Chandrika J Piyathilake   +6 more
doaj   +1 more source

LINE-1 methylation status and its association with tetralogy of fallot in infants

BMC Medical Genomics, 2012
Background Methylation levels of long interspersed nucleotide elements (LINE-1) are representative of genome-wide methylation status and play an important role in maintaining genomic stability and gene expression.
Sheng Wei, Wang Huijun, Ma Xiaojing, Qian Yanyan, Zhang Ping, Wu Yao, Zheng Fengyun, Chen Long, Huang Guoying, Ma Duan   +9 more
doaj   +1 more source

Holocene vegetation dynamics of Grande Terre (Kerguelen Islands) inferred from sedimentary ancient DNA

Journal of Quaternary Science, EarlyView.
ABSTRACT While the Antarctic region has experienced significant climatic changes over the Holocene, few high‐resolution records have examined their effects on the local biota. In order to understand past ecological shifts and forecast future changes, it is important to obtain high‐resolution palaeoecological records from this region.
Xaali O'Reilly‐Berkeley, Aloïs Revéret, Youri Lammers, Maaike Zwier, Anne E. Bjune, Fabien Arnaud, Jostein Bakke, Sandra Nogué, Inger G. Alsos   +8 more
wiley   +1 more source

SQuIRE: Software for Quantifying Interspersed Repeat Elements

, 2018
Transposable elements are interspersed repeat sequences that make up much of the human genome. Conventional approaches to RNA-seq analysis often exclude these sequences, fail to optimally adjudicate read alignments, or align reads to interspersed repeat ...
Lindsay M. Payer, Kathleen H. Burns, Clarissa N. Pacyna, Daniel Ardeljan, Wan R. Yang   +4 more
core   +1 more source

Impact of the GouM transporter on secondary metabolism activation and production yield in Streptomyces noursei strain CK‐15

New Plant Protection, EarlyView.
Overexpression of the gouM transporter gene in Streptomyces noursei CK‐15 enhances gougerotin production by 114% and activates silent biosynthetic gene clusters. This finding links transporter activity to metabolite efflux and secondary metabolism, offering a strategy for natural product discovery and strain optimization.
Qianying Zhou, Hua Yu, Rouhallah Sharifi, Muhammad Usman, Shun Lai Ei, Abdel‐Hamied M. Rasmey, Beibei Ge   +6 more
wiley   +1 more source

Long INterspersed nuclear Elements (LINEs) in brain and non-brain tissues of the rat [PDF]

, 2018
Long INterspersed Element-1 (L1) is a transposable element that can insert copies of itself in new genomic locations causing genomic instability. In somatic cells, L1 retrotransposition activity is usually repressed but somatic L1 retrotransposition has ...
Monti, Barbara, Brunella Del Re, Virgili, Marco, Del Re, Brunella, Gianfranco Giorgi, Barbara Monti, Marco Virgili, Giorgi, Gianfranco   +7 more
core   +1 more source

First genome sequence of a European Alternaria brassicae isolate and genes involved in early development of alternaria leaf spot on Brassica juncea

Pest Management Science, EarlyView.
This article reports the first genome sequence of a UK Alternaria brassicae isolate. Dual RNA‐sequencing profiling of A. brassicae‐infected Brassica juncea leaves identified differentially expressed genes involved in pathogenicity and host response pathways in moderately resistant Sej‐2 (2) and moderately susceptible Pusa Jaikisan cultivars.
Kevin M. King, Graham McLaughlin, Chinthani S. Karandeni Dewage, Zedi Gao, David J. Hughes, Jonathan S. West, Henrik U. Stotz   +6 more
wiley   +1 more source